METHYL 3-(2-AMINOETHOXY)BENZOATE

Base Information

• Chemical Name: METHYL 3-(2-AMINOETHOXY)BENZOATE
• CAS No.: 153938-41-1
• Molecular Formula: C10H13NO3
• Molecular Weight: 231.67600
• Hs Code.: 2922509090
• Mol file: 153938-41-1.mol

Synonyms:benzoic acid,3-(2-aminoethoxy)-,methyl ester;METHYL 3-(2-AMINOETHOXY)BENZOATE;methyl 3-(2-aminoethoxy)benzoate(SALTDATA: HCl);

Chemical Property of METHYL 3-(2-AMINOETHOXY)BENZOATE

Chemical Property:

• Vapor Pressure: 0.000392mmHg at 25°C
• Boiling Point: 317.2oC at 760 mmHg
• PKA: 8.36±0.10(Predicted)
• Flash Point: 148.5oC
• PSA: 61.55000
• Density: 1.138g/cm3
• LogP: 2.31300

Purity/Quality:

98%min ^*data from raw suppliers

methyl3-(2-aminoethoxy)benzoatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(2-AMINOETHOXY)BENZOATE

There total 3 articles about METHYL 3-(2-AMINOETHOXY)BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(2-{[( tert-butoxy)carbonyl]amino}ethoxy)benzoate (179002-82-5) → methyl 3-(2-aminoethoxy)benzoate (153938-41-1)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; for 3h;

DOI:10.1039/b800283e

Reference yield:

methyl 3-(cyanomethyloxy)benzoate (153938-40-0) → methyl 3-(2-aminoethoxy)benzoate (153938-41-1)

Guidance literature:

With hydrogenchloride; borane-THF; Yield given. Multistep reaction; 1.) THF, below 15 deg C, 1 h, 2.) THF, methanol;

DOI:10.1016/0223-5234(93)90093-T

Reference yield:

methyl 3-hydroxybenzoate (19438-10-9) → methyl 3-(2-aminoethoxy)benzoate (153938-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 3 h

2: 1.) BH₃*THF, 2.) HCl(gas) / 1.) THF, below 15 deg C, 1 h, 2.) THF, methanol

With hydrogenchloride; borane-THF; sodium hydride;

DOI:10.1016/0223-5234(93)90093-T

upstream raw materials:

methyl 3-(cyanomethyloxy)benzoate

methyl 3-hydroxybenzoate

methyl 3-(2-{[( tert-butoxy)carbonyl]amino}ethoxy)benzoate

Downstream raw materials:

C₁₅H₁₇NO₄

3-(2-{2-[(3-{2-[2-(3-amino-propoxy)-ethoxy]-ethoxy}-propylcarbamoyl)-methoxy]-acetylamino}-ethoxy)-benzoic acid methyl ester

Refernces

• 1、 Sartori, E.,Camy, F.,Teulon, J. M.,Caussade, F.,Virone-Oddos, A.,Cloarec, A.. "Synthesis and activities of new arylsulfonamido thromboxane A2 receptor antagonists". . p. 625 - 632. Retrieved 2007/10/02.