Technology Process of (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID
There total 8 articles about (+/-)-TRANS-N-BOC-4-METHYL-PIPECOLINIC ACID which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; sodium chlorite;
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite;
In
water; acetonitrile;
at 35 ℃;
for 18h;
pH=6.7;
DOI:10.1021/jo071220z
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaHCO3 / methanol / 16 h / 60 °C
2: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
3: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
4: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
5: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
6: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
With
sodium hypochlorite; sodium chlorite; sodium tetrahydroborate; sodium periodate; hydrogen; sodium hydrogencarbonate;
platinum(IV) oxide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo071220z
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
2: 27 g / NaBH4 / methanol / 0.5 h / 0 °C
3: 79 percent / 1st generation Grubbs catalyst / CH2Cl2 / 16 h / 20 °C
4: H2 / PtO2*H2O / ethyl acetate / 16 h / 2250.23 Torr
5: 63 percent / NaClO; NaClO2; sodoum phosphate buffer / TEMPO; bleach / acetonitrile; H2O / 18 h / 35 °C / pH 6.7
With
sodium hypochlorite; sodium chlorite; sodium tetrahydroborate; sodium periodate; hydrogen;
platinum(IV) oxide; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; Grubbs catalyst first generation;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo071220z
