2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

Base Information

• Chemical Name: 2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid
• CAS No.: 154365-43-2
• Molecular Formula: C10H8N2O6
• Molecular Weight: 252.18000
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70472932
• Mol file: 154365-43-2.mol

Synonyms:154365-43-2;2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid;2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylic acid;2-methyl-7-nitro-3-oxo-4H-1,4-benzoxazine-2-carboxylic acid;2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylicacid;SCHEMBL8632319;DTXSID70472932;MFCD08443984;AKOS005072116;CA-0859;CS-0320890;3,4-Dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid

Chemical Property of 2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

Chemical Property:

• PSA: 124.94000
• LogP: 1.37730
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 252.03823598
• Heavy Atom Count: 18
• Complexity: 406

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C(=O)NC2=C(O1)C=C(C=C2)[N+](=O)[O-])C(=O)O

Technology Process of 2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

There total 2 articles about 2-Methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester (154365-36-3) → 3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid (154365-43-2)

Guidance literature:

With lithium hydroxide; In methanol; for 12h;

DOI:10.1039/b400490f

Reference yield:

5-Nitro-2-aminophenol (121-88-0) → 3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid (154365-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / KF / dimethylformamide / 20 - 60 °C

2: 93 percent / NaOH / dioxane; H₂O / 24 h / 20 °C

With potassium fluoride; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2004.09.004

Reference yield: 86.0%

(L)-phenylalanine ethyl ester hydrochloride (3182-93-2) + 3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid (154365-43-2) → ethyl (2S)-2-{[(2-methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-phenylpropanoate (847671-59-4)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -10 - 20 ℃; pH=8;

DOI:10.1016/j.ejmech.2004.09.004

upstream raw materials:

3,4-dihydro-2-methyl-7-nitro-3-oxo-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester

5-Nitro-2-aminophenol

Downstream raw materials:

benzyl (2S)-1-{[(2R)-2-methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]carbonyl}-2-pyrrolidinecarboxylate

benzyl (2S)-1-{[(2S)-2-methyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]carbonyl}-2-pyrrolidinecarboxylate

ethyl (2S)-2-{[(2-methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-phenylpropanoate

ethyl (2S)-2-{[(7-amino-2-methyl-2H-1,4-benzoxazin-3(4H)-on-2-yl)carbonyl]amino}-3-phenylpropanoate