(20S)-3β,16β-Dihydroxypregn-5-ene-20-carboxylic acid γ-lactone

Base Information

• Chemical Name: (20S)-3β,16β-Dihydroxypregn-5-ene-20-carboxylic acid γ-lactone
• CAS No.: 33282-87-0
• Molecular Formula: C22H32 O3
• Molecular Weight: 344.4877
• Mol file: 33282-87-0.mol

Synonyms:Pregn-5-ene-20a-carboxylic acid, 3b,16b-dihydroxy-, g-lactone (8CI); 1H-Naphth[2',1':4,5]indeno[2,1-b]furan,pregnane deriv.; Diosgeninlactone; Vespertilin

Chemical Property of (20S)-3β,16β-Dihydroxypregn-5-ene-20-carboxylic acid γ-lactone

Chemical Property:

• Vapor Pressure: 2.88E-12mmHg at 25°C
• Boiling Point: 503.9°Cat760mmHg
• Flash Point: 202.9°C
• PSA: 46.53000
• Density: 1.16g/cm³
• LogP: 4.09770

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (20S)-3β,16β-Dihydroxypregn-5-ene-20-carboxylic acid γ-lactone

There total 11 articles about (20S)-3β,16β-Dihydroxypregn-5-ene-20-carboxylic acid γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-O-[α-L-rhamnopyranosyl-(1->4)]-α-L-rhamnopyranosyl-(1->2)-β-D-glucopyranosyl (22R,23S,25R,26R)-3β,23,26-trihydroxyspirost-5-ene → vespertilin (33282-87-0)

Guidance literature:

With hydrogenchloride; methanol; for 1h; Heating;

DOI:10.1016/S0040-4039(03)00689-0

Reference yield: 62.0%

3-O-[α-L-rhamnopyranosyl-(1->2)]-β-D-xylopyranosyl-(1->3)-β-D-glucopyranosyl (22R,23S,25R,26R)-3β,23,26-trihydroxyspirost-5-ene → vespertilin (33282-87-0)

Guidance literature:

With hydrogenchloride; methanol; Heating;

DOI:10.1016/S0040-4039(03)00689-0

Reference yield: 61.0%

3-O-[α-L-rhamnopyranosyl-(1->2)]-β-D-xylopyranosyl-(1->3)-β-D-glucopyranosyl 23,26-epoxy-3β,22,26-trihydroxyfurost-5-ene → vespertilin (33282-87-0)

Guidance literature:

With hydrogenchloride; methanol; Heating;

DOI:10.1016/S0040-4039(03)00689-0

upstream raw materials:

solasodine

(25R)-3β-acetoxyspirost-5-en-23-one

3β-acetoxy-16β-hydroxy-bisnor-5-en-cholanic acid (22->16) lactone

diosgenin acetate