4-Azidopyridine 1-oxide

Base Information

• Chemical Name: 4-Azidopyridine 1-oxide
• CAS No.: 10296-38-5
• Molecular Formula: C5H4 N4 O
• Molecular Weight: 136.113
• NSC Number: 526982
• DSSTox Substance ID: DTXSID70377559
• Nikkaji Number: J2.411.729D
• Mol file: 10296-38-5.mol

Synonyms:10296-38-5;4-Azidopyridine 1-oxide;4-azido-pyridine N-oxide;DTXSID70377559;NSC526982;4-Azido-1-oxo-1lambda~5~-pyridine;NSC-526982

Chemical Property of 4-Azidopyridine 1-oxide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 136.03851076
• Heavy Atom Count: 10
• Complexity: 240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN(C=CC1=N[N+]#N)[O-]
• Use Description: 1-(1-oxidopyridin-4-yl)triaza-1,2-dien-2-ium is a chemical compound with potential applications in various fields. In the field of coordination chemistry and catalysis, it may serve as a ligand or intermediate in the synthesis of organometallic complexes and catalysts. Its unique chemical structure could enable the development of catalysts for various chemical reactions, including those in the petrochemical industry, organic synthesis, and materials science. Additionally, in the pharmaceutical and medicinal sectors, this compound may find use as a key intermediate in the synthesis of pharmaceutical compounds, contributing to the development of medications targeting specific medical conditions. Its role and significance can vary, but it has the potential to play a pivotal role in advancing catalysis, drug development, and materials innovation across diverse scientific and industrial applications.

Technology Process of 4-Azidopyridine 1-oxide

There total 3 articles about 4-Azidopyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

4-hydrazinopyridine-1-oxide (50357-07-8) → 4-azidopyridine N-oxide (10296-38-5)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 0 - 20 ℃;

DOI:10.1021/jo061259o

Reference yield:

4-chloropyridine N-oxide (1121-76-2) → 4-azidopyridine N-oxide (10296-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine monohydrate / 0.5 h / Heating

2: 24 percent / NaNO₂; HCl / H₂O / 0 - 20 °C

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In water;

DOI:10.1021/jo061259o

Reference yield:

→ 4-azidopyridine N-oxide (10296-38-5)

Guidance literature:

4-Chlor-pyridin-(1)-oxyd, NaN3, Wasser, 175-185grad;

upstream raw materials:

4-hydrazinopyridine-1-oxide

4-chloropyridine N-oxide

Downstream raw materials:

4-methoxypyridine N-oxide

3-Bromo-1-oxy-pyridin-4-ylamine

4-aminopyridine-1-oxide

(E)-4-phenylazopyridine

Refernces

• 1、 Okamoto,Hayashi. "Reactions of N-aminopyridinium derivatives. VII. Reaction of n-aminopyridinium derivatives with diazonium salts". . p. 766 - 773. Retrieved 1966.