Technology Process of 1H-Imidazole-2-methanol,
5-butyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
There total 13 articles about 1H-Imidazole-2-methanol,
5-butyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-butyl-2-hydroxymethyl-1-<<2'-<(N-triphenylmethyl)tetrazol-5-yl>biphenyl-4-yl>methyl>imidazole;
With
triethylsilane; trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
With
hydrogenchloride;
In
water;
pH=3;
DOI:10.1016/j.ejmech.2012.07.040
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; toluene / 4 h / 100 °C / Inert atmosphere
3.1: trimethylsilylazide; trifluoroacetic acid / 36 h / 120 °C / Sealed tube
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 8 h / Reflux
6.1: acetonitrile / 12 h / 70 °C
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux
8.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 20 °C
8.2: pH 3
With
triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); trimethylsilylazide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; trifluoroacetic acid; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; toluene; acetonitrile;
2.1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2012.07.040
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: acetonitrile / 3 h / 70 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 85 °C / Sealed tube
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux
5.1: triethylsilane; trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5.2: pH 3
With
triethylsilane; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.07.040