Dacliximab

Base Information

• Chemical Name: Dacliximab
• CAS No.: 152923-56-3
• Molecular Weight: 0

Synonyms:Dacliximab;Daclizumab; Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 g-chain anti-human antigen Tac),disulfide with human-mouse monoclonal clone 1H4 light chain, dimer;Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 g-chain anti-human interleukin 2receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer;Ro 24-7375; Zenapax

Chemical Property of Dacliximab

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

DACLIZUMAB 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

• Uses: Dacliximab is monoclonal antibody (immunosuppressant.
• Clinical Use: Molecularly, daclizumab (Zenapax, Chimeric) is an IgG1MAb that binds specifically to the α subunit of the IL-2 receptor(the complete, high-affinity activated IL-2 receptorconsists of interacting α, β, and γ subunits). IL-2 receptorsare expressed on the surfaces of activated lymphocytes,where they mediate lymphocyte clonal expansion and differentiation.Daclizumab is a chimeric protein (90% humanand 10% mouse) IgG1. The MAb targets only recently activatedT cells that have interacted with antigen and have developedfrom their naive form into their activated form. Itis at this time that the IL-2 receptors are expressed. Thehuman amino acid sequences of daclizumab derive fromconstant domains of human IgG, and the variable domainsare derived from the fused Eu myeloma antibody. Themurine sequences derive from CDRs of a mouse anti-IL2αantibody.The indications for daclizumab are prophylaxis of acuteorgan rejection in patients receiving renal transplants, aspart of an immunosuppressant regimen including cyclosporineand corticosteroids. The mechanism of action isthe same as that of basiliximab.
• Drug interactions: Potentially hazardous interactions with other drugsAvoid live vaccines.

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