4-Oxazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-, (4S)-

Base Information

• Chemical Name: 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-, (4S)-
• CAS No.: 155880-02-7
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.186
• Mol file: 155880-02-7.mol

Synonyms:

Chemical Property of 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-, (4S)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-, (4S)-

There total 12 articles about 4-Oxazolecarboxylic acid, 4,5-dihydro-2-(2-hydroxyphenyl)-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.8%

methyl (4S)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate (370590-36-6) → (4S)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-02-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.1c01966

Reference yield: 65.0%

benzyl 2-(2'-hydroxyphenyl)-4(S)-oxazolinecarboxylate → (4S)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-02-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00036a005

Reference yield: 41.2%

(2S)-3-hydroxy-2-[(2-hydroxybenzoyl)amino]propanoic acid (37592-64-6) → (4S)-2-[2-hydroxyphenyl]-Δ2-1,3-oxazoline-4-carboxylic acid (155880-02-7)

Guidance literature:

With diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane; at -20 ℃; for 2h;

DOI:10.1021/acs.joc.1c01966

upstream raw materials:

(4S)-benzyl 2-[2-(benzyloxy)phenyl]-Δ²-1,3-oxazoline-4-carboxylate

2-benzyloxybenzoic acid

(S)-benzyl 2-(2-(benzyloxy)benzamido)-3-hydroxypropanoate

methyl salicylate

Downstream raw materials:

(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

(S)-6-[Hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

(S)-6-[Hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

(2S)-6-formamido-2-[(4R)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid