Propanedioic acid, methyl[(2E)-3-phenyl-2-propenyl]-, diethyl ester

Base Information

• Chemical Name: Propanedioic acid, methyl[(2E)-3-phenyl-2-propenyl]-, diethyl ester
• CAS No.: 156382-65-9
• Molecular Formula: C17H22O4
• Molecular Weight: 290.359
• Mol file: 156382-65-9.mol

Synonyms:

Chemical Property of Propanedioic acid, methyl[(2E)-3-phenyl-2-propenyl]-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, methyl[(2E)-3-phenyl-2-propenyl]-, diethyl ester

There total 16 articles about Propanedioic acid, methyl[(2E)-3-phenyl-2-propenyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Diethyl methylmalonate (609-08-5) → 2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester (156382-65-9)

Guidance literature:

Diethyl methylmalonate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

cinnamyl halide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201204119

Reference yield: 94.0%

Cinnamyl acetate (21040-45-9) + Diethyl methylmalonate (609-08-5) → 2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester (156382-65-9)

Guidance literature:

With potassium carbonate; Triton X-100; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; at 30 ℃; for 2h;

DOI:10.1016/S0040-4039(00)01027-3

Reference yield: 81.0%

Cinnamyl bromide (4392-24-9) + Diethyl methylmalonate (609-08-5) → 2-methyl-2-(3-phenyl-2-propenyl)malonic acid diethyl ester (156382-65-9)

Guidance literature:

Diethyl methylmalonate; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Cinnamyl bromide; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 7h; Inert atmosphere;

DOI:10.1039/c3ob40315g

upstream raw materials:

Cinnamyl acetate

sodium diethyl methylmalonate

trans-3-phenylprop-2-enyl chloride

Diethyl methylmalonate