Benzene, [[(2S,6R)-2,6-dimethyl-8-(phenylmethoxy)octyl]sulfonyl]-

Base Information

• Chemical Name: Benzene, [[(2S,6R)-2,6-dimethyl-8-(phenylmethoxy)octyl]sulfonyl]-
• CAS No.: 156592-97-1
• Molecular Formula: C23H32O3S
• Molecular Weight: 388.571
• Mol file: 156592-97-1.mol

Synonyms:

Chemical Property of Benzene, [[(2S,6R)-2,6-dimethyl-8-(phenylmethoxy)octyl]sulfonyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, [[(2S,6R)-2,6-dimethyl-8-(phenylmethoxy)octyl]sulfonyl]-

There total 17 articles about Benzene, [[(2S,6R)-2,6-dimethyl-8-(phenylmethoxy)octyl]sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-Hydroxy-3-methyl-butyric acid (77220-86-1,108772-87-8) → (2S,6R)-8-(benzyloxy)-1-(phenylsulfonyl)-2,6-dimethyloctane (156592-97-1)

Guidance literature:

Multi-step reaction with 13 steps

1: imidazole / dimethylformamide

2: DIBAH

3: TfOH / diethyl ether

4: aq. HCl / tetrahydrofuran

5: pyridine

6: K₂CO₃ / dimethylformamide

7: m-CPBA / CH₂Cl₂

8: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT

9: 86 percent / Na(Hg) / methanol

10: aq. HCl / tetrahydrofuran

11: pyridine

12: K₂CO₃ / dimethylformamide

13: m-CPBA / CH₂Cl₂

With pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c39940000137

Reference yield:

(S)-4-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-butyric acid (862387-31-3) → (2S,6R)-8-(benzyloxy)-1-(phenylsulfonyl)-2,6-dimethyloctane (156592-97-1)

Guidance literature:

Multi-step reaction with 12 steps

1: DIBAH

2: TfOH / diethyl ether

3: aq. HCl / tetrahydrofuran

4: pyridine

5: K₂CO₃ / dimethylformamide

6: m-CPBA / CH₂Cl₂

7: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT

8: 86 percent / Na(Hg) / methanol

9: aq. HCl / tetrahydrofuran

10: pyridine

11: K₂CO₃ / dimethylformamide

12: m-CPBA / CH₂Cl₂

With pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c39940000137

Reference yield:

(3S)-4-<(1-ethoxyethyl)oxy>-3-methylbutanenitrile (188692-77-5) → (2S,6R)-8-(benzyloxy)-1-(phenylsulfonyl)-2,6-dimethyloctane (156592-97-1)

Guidance literature:

Multi-step reaction with 14 steps

1: aq. HCl / tetrahydrofuran

2: imidazole / dimethylformamide

3: DIBAH

4: TfOH / diethyl ether

5: aq. HCl / tetrahydrofuran

6: pyridine

7: K₂CO₃ / dimethylformamide

8: m-CPBA / CH₂Cl₂

9: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT

10: 86 percent / Na(Hg) / methanol

11: aq. HCl / tetrahydrofuran

12: pyridine

13: K₂CO₃ / dimethylformamide

14: m-CPBA / CH₂Cl₂

With pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c39940000137

upstream raw materials:

thiophenol

O-benzyl 2,2,2-trichloroacetimidate

(S)-4-(benzyloxy)-2-methylbutan-1-ol

(S)-4-Hydroxy-3-methyl-butyric acid

Downstream raw materials:

(2S,6R,10S,14R)-16-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,6,10,14-tetramethyl-8-(phenylsulfonyl)hexadecane

(3R,7S,11R)-1-benzyloxy-3,7,11,15-tetramethyl-8-phenylsulfonyl-14-hexadecene

(4S,8R,12R)-14-[(S)-2-Benzyloxy-1-((3R,7R,11S)-14-hydroxy-3,7,11-trimethyl-tetradecyloxymethyl)-ethoxy]-4,8,12-trimethyl-tetradecan-1-ol

[(S)-2,3-Bis-((3R,7R,11S)-3,7,11,15-tetramethyl-hexadec-14-enyloxy)-propoxymethyl]-benzene