3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine
• CAS No.: 156817-72-0
• Molecular Formula: C7H9BrN2
• Molecular Weight: 201.06400
• Hs Code.: 2933990090
• European Community (EC) Number: 807-502-6
• DSSTox Substance ID: DTXSID90434496
• Wikidata: Q82248932
• Mol file: 156817-72-0.mol

Synonyms:3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine;156817-72-0;3-bromo-5H,6H,7H,8H-imidazo[1,2-a]pyridine;MFCD08751337;IMIDAZO[1,2-A]PYRIDINE, 3-BROMO-5,6,7,8-TETRAHYDRO-;SCHEMBL3549518;DTXSID90434496;CDQPJEFLGBLJKS-UHFFFAOYSA-N;BBL100374;STL554168;AKOS007929996;AB48889;CS-W006086;FS-2620;AM803268;EN300-96319;3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine, AldrichCPR

Chemical Property of 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

Chemical Property:

• Boiling Point: 346.3±15.0 °C(Predicted)
• PKA: 5.91±0.20(Predicted)
• PSA: 17.82000
• Density: 1.73±0.1 g/cm3(Predicted)
• LogP: 1.98190
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 199.99491
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN2C(=NC=C2Br)C1

Technology Process of 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

There total 5 articles about 3-Bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE (34167-66-3) → 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (156817-72-0)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 0.5h; Heating;

DOI:10.1021/jo00096a066

Reference yield:

5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE (34167-66-3) → 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (156817-72-0) + 2,3-Dibromo-5,6,7,8-tetrahydroimidazo<1,2-a>pyridine

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; Heating;

DOI:10.1021/jo00096a066

Reference yield:

methyl 5-chloropentanimidate → 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine (156817-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: formic acid / 6 h / 100 °C

3: N-Bromosuccinimide / tetrachloromethane / 16 h / 20 °C

With N-Bromosuccinimide; formic acid; triethylamine; In tetrachloromethane; dichloromethane;

upstream raw materials:

5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE

δ-chlorovaleronitrile

Downstream raw materials:

5,6,7,8-tetrahydroimidazo<1,2-a>pyridine-3-carbaldehyde