Technology Process of 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (S)-
There total 14 articles about 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminum oxide; pyridinium chlorochromate;
In
dichloromethane;
at 23 ℃;
for 8h;
Yield given;
DOI:10.1016/S0040-4039(00)73170-4
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / 10 percent Pd/C / ethyl acetate / 10 h / 23 °C / 760 Torr
2: Bu4NF / tetrahydrofuran / 3 h / 23 °C
3: DEAD, Ph3P / tetrahydrofuran / 0.5 h / 23 °C
4: NaOMe / methanol; tetrahydrofuran / 3 h / 23 °C
5: imidazole, DMAP / dimethylformamide / 3 h / 50 °C
6: HOAc, water / tetrahydrofuran / 14 h / 70 °C
7: PCC, Al2O3 / CH2Cl2 / 8 h / 23 °C
With
1H-imidazole; dmap; aluminum oxide; tetrabutyl ammonium fluoride; water; hydrogen; sodium methylate; acetic acid; triphenylphosphine; pyridinium chlorochromate; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73170-4
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) Tf2O; 2.) DBU / 1.) C5H5N, CH2Cl2, 0 deg C, 2 h; 2.) 23 deg C, 10 h
2: H2 / 10 percent Pd/C / ethyl acetate / 10 h / 23 °C / 760 Torr
3: Bu4NF / tetrahydrofuran / 3 h / 23 °C
4: DEAD, Ph3P / tetrahydrofuran / 0.5 h / 23 °C
5: NaOMe / methanol; tetrahydrofuran / 3 h / 23 °C
6: imidazole, DMAP / dimethylformamide / 3 h / 50 °C
7: HOAc, water / tetrahydrofuran / 14 h / 70 °C
8: PCC, Al2O3 / CH2Cl2 / 8 h / 23 °C
With
1H-imidazole; dmap; aluminum oxide; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; water; hydrogen; sodium methylate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; pyridinium chlorochromate; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)73170-4