(4-Amino-6-methylpyridin-3-yl)methanol

Base Information

• Chemical Name: (4-Amino-6-methylpyridin-3-yl)methanol
• CAS No.: 15742-82-2
• Molecular Formula: C7H10N2O
• DSSTox Substance ID: DTXSID70562665
• Mol file: 15742-82-2.mol

Synonyms:(4-Amino-6-methylpyridin-3-yl)methanol;15742-82-2;3-Pyridinemethanol, 4-amino-6-methyl-;SCHEMBL10330646;DTXSID70562665;AKOS006337218;AS-63076;2-methyl-4-amino-5-hydroxymethyl pyridine;CS-0186071;C72979;A907669

Chemical Property of (4-Amino-6-methylpyridin-3-yl)methanol

Chemical Property:

• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=N1)CO)N

Technology Process of (4-Amino-6-methylpyridin-3-yl)methanol

There total 11 articles about (4-Amino-6-methylpyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Amino-6-methyl-3-pyridincarbonsaeure-ethylester (90437-51-7) → 4-Amino-5-(hydroxymethyl)-2-methylpyridin (15742-82-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h;

Reference yield:

5-ethyl-2-methylpyridine-N-oxide (768-44-5) → 4-Amino-5-(hydroxymethyl)-2-methylpyridin (15742-82-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 81 percent / konz. H₂SO₄/HNO₃

2: 80 percent / Fe, Eisessig / 2 h

3: 85 percent / acetic anhydride / 5 h / Heating

4: 98 percent / konz. H₂SO₄, CrO₃ / acetic acid / 1.5 h / 10 - 15 °C

5: 92 percent / 10percent HCl / 1 h / Heating

6: 78 percent / HBr, Eisessig, Pyridindibromid-hydrobromid / 60 °C

7: 98 percent / 1 h / 50 °C

8: 3percent NaOH / 1.5 h / Ambient temperature

9: konz. H₂SO₄ / 4 h / Heating

10: 85 percent / LiAlH₄ / diethyl ether / 2 h

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; pyridinium perbromide hydrobromide; sulfuric acid; hydrogen bromide; nitric acid; iron; acetic acid; In diethyl ether; acetic anhydride; acetic acid;

Reference yield:

4-Amino-5-ethyl-2-methylpyridin (5350-64-1) → 4-Amino-5-(hydroxymethyl)-2-methylpyridin (15742-82-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 85 percent / acetic anhydride / 5 h / Heating

2: 98 percent / konz. H₂SO₄, CrO₃ / acetic acid / 1.5 h / 10 - 15 °C

3: 92 percent / 10percent HCl / 1 h / Heating

4: 78 percent / HBr, Eisessig, Pyridindibromid-hydrobromid / 60 °C

5: 98 percent / 1 h / 50 °C

6: 3percent NaOH / 1.5 h / Ambient temperature

7: konz. H₂SO₄ / 4 h / Heating

8: 85 percent / LiAlH₄ / diethyl ether / 2 h

With chromium(VI) oxide; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; pyridinium perbromide hydrobromide; sulfuric acid; hydrogen bromide; acetic acid; In diethyl ether; acetic anhydride; acetic acid;

upstream raw materials:

4-Amino-6-methyl-3-pyridincarbonsaeure-ethylester

5-ethyl-2-methylpyridine-N-oxide

4-Amino-5-ethyl-2-methylpyridin

5-Ethyl-2-methyl-4-nitropyridin-N-oxid

Refernces