Benzenemethanol, 4-(dimethylamino)-a-ethynyl-

Base Information

• Chemical Name: Benzenemethanol, 4-(dimethylamino)-a-ethynyl-
• CAS No.: 1574-85-2
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol file: 1574-85-2.mol

Synonyms:1-[4'-(dimethylamino)phenyl]prop-2-ynol;(S)-1-(4-Dimethylamino-phenyl)-prop-2-yn-1-ol;

Chemical Property of Benzenemethanol, 4-(dimethylamino)-a-ethynyl-

Chemical Property:

• Melting Point: 71.5 - 72 °C (hexane)
• Boiling Point: 294.9±30.0 °C(Predicted)
• PSA: 23.47000
• Density: 1.103±0.06 g/cm3(Predicted)
• LogP: 1.41920

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, 4-(dimethylamino)-a-ethynyl-

There total 6 articles about Benzenemethanol, 4-(dimethylamino)-a-ethynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethylmagnesium bromide (925-90-6) + 4-dimethylamino-benzaldehyde (100-10-7) → 4-dimethylamino-α-(ethynyl)-benzenemethanol (1574-85-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.macromol.9b02633

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) + trimethylsilylacetylene (1066-54-2) → 4-dimethylamino-α-(ethynyl)-benzenemethanol (1574-85-2)

Guidance literature:

trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

4-dimethylamino-benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With methanol; potassium carbonate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02263

Reference yield:

4-dimethylamino-benzaldehyde (100-10-7) + acetylenemagnesium bromide (4301-14-8) → 4-dimethylamino-α-(ethynyl)-benzenemethanol (1574-85-2)

Guidance literature:

In tetrahydrofuran;

DOI:10.1039/jr9650002983

upstream raw materials:

4-dimethylamino-benzaldehyde

acetylenemagnesium bromide

trimethylsilylacetylene

ethylmagnesium bromide

Downstream raw materials:

1-p-Dimethylaminophenylhexa-2,4-di-in-1-ol

1-p-Dimethylaminophenylhexa-2,4-di-in-1-on

1-(4-dimethylaminophenyl)-3-(4-pyridinyl)-2-propyne-1-one

[4-(1-allyloxy-prop-2-ynyl)-phenyl]-dimethylamine