2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-[(1,1-dimethylethoxy)carbonyl]-3,4-dimethyl-1H-pyrrol-2-yl]methyl]- 4,5-dihydro-, phenylmethyl ester

Base Information

• Chemical Name: 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-[(1,1-dimethylethoxy)carbonyl]-3,4-dimethyl-1H-pyrrol-2-yl]methyl]- 4,5-dihydro-, phenylmethyl ester
• CAS No.: 159469-70-2
• Molecular Formula: C32H34N2O4
• Molecular Weight: 510.633
• Mol file: 159469-70-2.mol

Synonyms:

Chemical Property of 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-[(1,1-dimethylethoxy)carbonyl]-3,4-dimethyl-1H-pyrrol-2-yl]methyl]- 4,5-dihydro-, phenylmethyl ester

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Technology Process of 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-[(1,1-dimethylethoxy)carbonyl]-3,4-dimethyl-1H-pyrrol-2-yl]methyl]- 4,5-dihydro-, phenylmethyl ester

There total 4 articles about 2H-Benz[e]isoindole-1-carboxylic acid, 3-[[5-[(1,1-dimethylethoxy)carbonyl]-3,4-dimethyl-1H-pyrrol-2-yl]methyl]- 4,5-dihydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,4-dimethyl-1H-pyrrole-2-carbonic acid tert-butyl ester (50634-34-9) + benzyl 3-acetoxymethyl-4,5-dihydronaphtho<1,2-c>pyrrole-1-carboxylate (159469-62-2) → benzyl 3-(5-tert-butyloxycarbonyl-3,4-dimethylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-70-2)

Guidance literature:

With Montmorillonite clay K₁₀; In dichloromethane;

DOI:10.1021/jo040269r

Reference yield:

2-acetyl-1-tetralone (17216-08-9) → benzyl 3-(5-tert-butyloxycarbonyl-3,4-dimethylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-70-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / acetic acid / Heating

2: NaOCH₂Ph

3: acetic acid

4: Montmorillonite Clay

With montmorillonite clay; sodium phenyl-methanolate; In acetic acid;

DOI:10.1016/0040-4039(94)80100-2

Reference yield:

Ethyl 3-methyl-4,5-dihydro-2H-benzoisoindole-1-carboxylate (81979-59-1) → benzyl 3-(5-tert-butyloxycarbonyl-3,4-dimethylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate (159469-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOCH₂Ph

2: acetic acid

3: Montmorillonite Clay

With montmorillonite clay; sodium phenyl-methanolate; In acetic acid;

DOI:10.1016/0040-4039(94)80100-2

upstream raw materials:

3,4-dimethyl-1H-pyrrole-2-carbonic acid tert-butyl ester

benzyl 3-acetoxymethyl-4,5-dihydronaphtho<1,2-c>pyrrole-1-carboxylate

2-acetyl-1-tetralone

Ethyl 3-methyl-4,5-dihydro-2H-benzoisoindole-1-carboxylate

Downstream raw materials:

benzyl 3-(5-formyl-3,4-dimethylpyrrol-2-ylmethyl)-4,5-dihydronaphtho[1,2-c]pyrrole-1-carboxylate

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