4-Morpholino-2-naphthol

Base Information

• Chemical Name: 4-Morpholino-2-naphthol
• CAS No.: 159596-05-1
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• European Community (EC) Number: 435-700-9
• DSSTox Substance ID: DTXSID00450940
• Nikkaji Number: J1.081.955E
• Wikidata: Q82270783
• Mol file: 159596-05-1.mol

Synonyms:4-morpholino-2-naphthol;159596-05-1;4-morpholin-4-ylnaphthalen-2-ol;4-Morpholinonaphthalen-2-ol;2-Naphthalenol, 4-(4-morpholinyl)-;SCHEMBL5616457;DTXSID00450940;IPHLOJFBRZIUGM-UHFFFAOYSA-N;4-(MORPHOLIN-4-YL)NAPHTHALEN-2-OL

Chemical Property of 4-Morpholino-2-naphthol

Chemical Property:

• Boiling Point: 461.3±40.0 °C(Predicted)
• PKA: 10.07±0.40(Predicted)
• PSA: 32.70000
• Density: 1.237±0.06 g/cm3(Predicted)
• LogP: 2.44700
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 229.110278721
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC(=CC3=CC=CC=C32)O

Technology Process of 4-Morpholino-2-naphthol

There total 2 articles about 4-Morpholino-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-4-morpholinonaphthalen-2-ol (159596-04-0) → 4-morpholino-2-naphthol (159596-05-1)

Guidance literature:

In sodium hydroxide; palladium on charcoal; ethanol;

Reference yield:

→ 4-morpholino-2-naphthol (159596-05-1)

Guidance literature:

Reference yield: 90.8%

4-morpholino-2-naphthol (159596-05-1) + C6H4ClFN2 → (Z)-1-[2-(2-fluorophenyl)hydrazineylidene]-4-morpholinonaphthalen-2(1H)-one

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1016/j.dyepig.2021.109678

upstream raw materials:

1-chloro-4-morpholinonaphthalen-2-ol

Downstream raw materials:

3,3-bis(4-methoxyphenyl)-6-morpholino-3H-naphtho[2,1-b]pyran

3-(4-piperidinophenyl)-3-phenyl-6-morpholino-3H-naphtho[2,1-b]pyran

3,3-diphenyl-6-morpholino-3H-naphtho[2,1-b]pyran