5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID

Base Information

Chemical Name:5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID
CAS No.:16089-46-6
Molecular Formula:C11H14N2O2
Molecular Weight:206.244
Hs Code.:2933990090
Mol file:16089-46-6.mol

Synonyms:5-amino-2-pyrrolidino-benzoic acid;5-amino-2-phenylazoimidazole-4-carboxamide;

Suppliers and Price of 5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-Amino-2-pyrrolidin-1-yl-benzoic acid
500mg
$ 213.00

Matrix Scientific
5-Amino-2-pyrrolidin-1-yl-benzoic acid
1g
$ 328.00

Crysdot
5-Amino-2-(Pyrrolidin-1-yl)benzoicacid 95+%
1g
$ 310.00

Chemenu
5-Amino-2-(Pyrrolidin-1-yl)benzoicacid 95%
1g
$ 293.00

American Custom Chemicals Corporation
5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID 95.00%
500MG
$ 796.95

AK Scientific
5-Amino-2-pyrrolidin-1-yl-benzoicacid
1g
$ 492.00

Total 3 raw suppliers

Chemical Property of 5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID

Chemical Property:

Boiling Point:445.7±40.0 °C(Predicted)
PKA:2.99±0.36(Predicted)
PSA：66.56000
Density:1.298±0.06 g/cm3(Predicted)
LogP:2.21340

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-2-pyrrolidin-1-yl-benzoic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID

There total 2 articles about 5-AMINO-2-PYRROLIDIN-1-YL-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 19555-48-7
2-tetrahydropyrrolyl-5-nitrobenzoic acid

: 16089-46-6
5-amino-2-pyrrolidino-benzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide; at 20 ℃; for 1h; under 750.06 Torr;
DOI:10.1021/jm9810349

Reference yield:

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 16089-46-6
5-amino-2-pyrrolidino-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / ethanol / 7 h / Heating

2: 79 percent / H₂ / 10 percent Pd/C / dimethylformamide / 1 h / 20 °C / 750.06 Torr

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9810349

Reference yield:

: 16089-46-6
5-amino-2-pyrrolidino-benzoic acid

: 4-[2-(5-chloro-2-pyrrolidin-1-yl-benzoylamino)-ethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. NaNO₂, HCl, 2.) Cu, aq. HCl / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 2 h, 2.) THF, RT, overnight

3: 68 percent / aq. KOH / dioxane; methanol / Ambient temperature

With hydrogenchloride; potassium hydroxide; copper; 1,1'-carbonyldiimidazole; sodium nitrite; In 1,4-dioxane; methanol;
DOI:10.1021/jm9810349