Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate

Base Information

Chemical Name:Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate
CAS No.:161126-45-0
Molecular Formula:C12H9NO4
Molecular Weight:231.208
Hs Code.:
DSSTox Substance ID:DTXSID80576197
Nikkaji Number:J635.920E
Wikidata:Q82465759
Mol file:161126-45-0.mol

Synonyms:161126-45-0;Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate;DTXSID80576197

Suppliers and Price of Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:231.05315777
Heavy Atom Count:17
Complexity:288

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(ON=C1C2=CC=CC=C2)C=O

Technology Process of Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate

There total 5 articles about Methyl 5-formyl-3-phenyl-1,2-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 682352-72-3
5-hydroxymethyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester

: 161126-45-0
5-formyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.tet.2004.01.009

Reference yield:

: 2065-28-3
methyl 5-methyl-3-phenylisoxazole-4-carboxylate

: 161126-45-0
5-formyl-3-phenyl-isoxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NBS / CCl₄ / 24 h / 40 - 45 °C / UV-irradiation

1.2: 93 percent / H₂O / dimethylsulfoxide / 4 h / 80 °C

2.1: 82 percent / PCC / CH₂Cl₂ / 10 h / 20 °C

With N-Bromosuccinimide; pyridinium chlorochromate; In tetrachloromethane; dichloromethane;
DOI:10.1016/j.tet.2004.01.009