1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)-
CAS No.:161275-47-4
Molecular Formula:C41H53N3O7Si
Molecular Weight:727.973
Hs Code.:
Mol file:161275-47-4.mol

1-Pyrrolidinecarboxylic acid,
2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1-
dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-,
2-propenyl ester, (2Z,3R,4R,5S)-

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)-

Chemical Property:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)-

There total 12 articles about 1-Pyrrolidinecarboxylic acid, 2-[1-(benzoylamino)-2-[(1-methylethyl)amino]-2-oxoethylidene]-5-[[[(1,1- dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-, 2-propenyl ester, (2Z,3R,4R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 75-31-0
isopropylamine

: 560130-36-1
(2S,3R,4R)-3,4-Bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-[5-oxo-2-phenyl-oxazol-(4E)-ylidene]-pyrrolidine-1-carboxylic acid allyl ester

: 161150-49-8
(3R,4R,5S)-2-[(E)-1-benzoylamino-1-[N-(1-methylethyl)carbamoyl]methylidene]-3,4-dibenzyloxy-1-(2-propenyloxy)carbonyl-5-(t-butyldimethylsiloxy)methylpyrrolidine

: 161275-47-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[N-(1-methylethyl)carbamoyl]methylidene]-3,4-dibenzyloxy-1-(2-propenyloxy)carbonyl-5-(t-butyldimethylsiloxy)methylpyrrolidine

Guidance literature:: Ambient temperature;
DOI:10.1016/S0040-4039(00)78556-X

Reference yield:

: 176298-13-8
4-[(3R,4R,5S)-3,4-dibenzyloxy-5-(t-butyldimethylsiloxymethyl)pyrrolidin-2-ylidene]-2-phenyl-4H-oxazol-5-one

: 161275-47-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[N-(1-methylethyl)carbamoyl]methylidene]-3,4-dibenzyloxy-1-(2-propenyloxy)carbonyl-5-(t-butyldimethylsiloxy)methylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / tetrahydrofuran / 0.5 h / 20 °C

2: 20 percent / DMAP / tetrahydrofuran / 0.5 h / 20 °C

With dmap; In tetrahydrofuran;
DOI:10.1016/S0040-4020(03)00378-8

Reference yield:

: 161150-47-6
(2S,3R,4S)-3,4-dibenzyloxy-2-(t-butyldimethylsiloxy)methyl-5-methylthio-3,4-dihydro-2H-pyrrole

: 161275-47-4
(3R,4R,5S)-2-[(Z)-1-benzoylamino-1-[N-(1-methylethyl)carbamoyl]methylidene]-3,4-dibenzyloxy-1-(2-propenyloxy)carbonyl-5-(t-butyldimethylsiloxy)methylpyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / toluene / 80 °C

2: DMAP / tetrahydrofuran / 0.5 h / 20 °C

3: 20 percent / DMAP / tetrahydrofuran / 0.5 h / 20 °C

With dmap; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(03)00378-8