Dexamethasone 17-propionate

Base Information

• Chemical Name: Dexamethasone 17-propionate
• CAS No.: 15423-89-9
• Molecular Formula: C₂₅H₃₃FO₆
• Molecular Weight: 448.532
• Hs Code.: 2915900090
• DSSTox Substance ID: DTXSID50934962
• Wikidata: Q82910957
• Mol file: 15423-89-9.mol

Synonyms:dexamethasone 17-propionate;DX-17P

Chemical Property of Dexamethasone 17-propionate

Chemical Property:

• Vapor Pressure: 7.68E-16mmHg at 25°C
• Boiling Point: 579.5°Cat760mmHg
• Flash Point: 304.3°C
• PSA: 100.90000
• Density: 1.28g/cm³
• LogP: 2.85660
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 448.22611693
• Heavy Atom Count: 32
• Complexity: 925

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Dexamethasone17-Propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO
• Isomeric SMILES: CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO
• Recent EU Clinical Trials: A randomized placebo-controlled phase II study of clarithromycin or placebo
• Uses: A Dexamethasone Dipropionate metabolite.

Technology Process of Dexamethasone 17-propionate

There total 6 articles about Dexamethasone 17-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Dexamethasone 17α,21-ethyl orthopropanoate (25122-24-1) → dexamethasone 17-propionate (15423-89-9)

Guidance literature:

aluminium silicate; In methanol; water; for 1h; Heating;

DOI:10.1055/s-1984-30941

Reference yield:

→ Betamethason-17-valeriat (5534-13-4,15423-89-9)

Guidance literature:

Betamethason-17-valeriat-21-phosphat-Natrium-Salz;

Reference yield:

→ Propionic acid (R)-9-fluoro-11-hydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester (5534-13-4,15423-89-9)

Guidance literature:

entspr. 17,21-(1'-Ethoxy-1'-ethylmethylendioxy)-Verb., 2n-H2SO4;

upstream raw materials:

Dexamethasone 17α,21-ethyl orthopropanoate

Refernces