3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-

Base Information

Chemical Name:3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-
CAS No.:162466-21-9
Molecular Formula:C12H17NO2
Molecular Weight:207.272
Hs Code.:
DSSTox Substance ID:DTXSID10448419
Nikkaji Number:J1.827.002A
Wikidata:Q82267399
Mol file:162466-21-9.mol

Synonyms:162466-21-9;(2S,3S,4S)-1-BENZYL-2-METHYLPYRROLIDINE-3,4-DIOL;3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-;SCHEMBL17426073;DTXSID10448419;(2S)-1-Benzyl-2beta-methylpyrrolidine-3alpha,4beta-diol

Suppliers and Price of 3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:207.125928785
Heavy Atom Count:15
Complexity:204

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(CN1CC2=CC=CC=C2)O)O
Isomeric SMILES:C[C@H]1[C@@H]([C@H](CN1CC2=CC=CC=C2)O)O

Technology Process of 3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)-

There total 7 articles about 3,4-Pyrrolidinediol, 2-methyl-1-(phenylmethyl)-, (2S,3S,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 502841-26-1
(2S,3S,4S)-1-Benzyl-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pyrrolidine

: 162466-21-9
(2S,3S,4S)-1-Benzyl-2-methyl-pyrrolidine-3,4-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/jhet.5570390525

Reference yield:

: 75172-31-5
(3R,4R)-1-benzyl-3,4-dihydroxypyrrolidine-2,5-dione

: 162466-21-9
(2S,3S,4S)-1-Benzyl-2-methyl-pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / imidazole / dimethylformamide / 12 h / 25 °C

2: 81.7 percent / tetrahydrofuran / 6 h / 0 °C

3: 88 percent / BF₃*OEt₂; Et₃SiH / CH₂Cl₂

4: 88 percent / Me₂S*BH₃ / tetrahydrofuran / 20 °C

5: 93 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With 1H-imidazole; triethylsilane; dimethylsulfide borane complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570390525

Reference yield:

: (3R,4R)-1-Benzyl-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-5-methyl-pyrrolidin-2-one

: 162466-21-9
(2S,3S,4S)-1-Benzyl-2-methyl-pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / BF₃*OEt₂; Et₃SiH / CH₂Cl₂

2: 88 percent / Me₂S*BH₃ / tetrahydrofuran / 20 °C

3: 93 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

With triethylsilane; dimethylsulfide borane complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570390525