1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-9-methyl-

Base Information

• Chemical Name: 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-9-methyl-
• CAS No.: 16502-02-6
• Molecular Formula: C12H14N2
• Molecular Weight: 186.25300
• Mol file: 16502-02-6.mol

Synonyms:9-methyl-1,2,3,4-tetrahydro-β-carboline;9-methyl-1,2,3,4-tetrahydro-b-carboline;9-methyltryptoline;1,2,3,4-tetrahydro-9-methyl-pyrido[3,4-b]indole;9-Methyl-1,2,3,4-tetrahydropyrido[3,4-b]indole;

Chemical Property of 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-9-methyl-

Chemical Property:

• PSA: 16.96000
• LogP: 2.15280

Purity/Quality:

2,3,4,9-tetrahydro-9-methyl-1H-Pyrido[3,4-b]indole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-9-methyl-

There total 21 articles about 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-9-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzyl-7-chloro-9-methyl-1,2,3,4-tetrahydro-1H-β-carboline (606926-49-2) → 9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (16502-02-6)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 15h; under 1900 Torr;

DOI:10.1016/S0040-4020(03)00824-X

Reference yield: 67.0%

1,3,5-Trioxan (110-88-3) + tetrahydrobetacarboline (16502-01-5) → 9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (16502-02-6)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 48h; chemoselective reaction; Inert atmosphere;

DOI:10.1055/s-0034-1381049

Reference yield:

2-t-butoxycarbonyl-9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (177858-73-0) → 9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (16502-02-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

upstream raw materials:

9-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one

2-(1-methyl-1H-indol-3-yl)ethylamine

2-benzyloxycarbonyl-9-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole

2-benzyl-7-chloro-9-methyl-1,2,3,4-tetrahydro-1H-β-carboline

Downstream raw materials:

9-methylnorharmane

2-(9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)benzaldehyde