5-Bromo-3-methyl-2-azanaphthalene

Base Information

• Chemical Name: 5-Bromo-3-methyl-2-azanaphthalene
• CAS No.: 16552-67-3
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.08100
• Hs Code.: 2933499090
• Mol file: 16552-67-3.mol

Synonyms:5-Bromo-3-methylisoquinoline;5-Brom-3-methyl-isochinolin;3-Methyl-5-bromoisoquinoline;

Chemical Property of 5-Bromo-3-methyl-2-azanaphthalene

Chemical Property:

• Boiling Point: 315.6±22.0 °C(Predicted)
• PKA: 4.68±0.43(Predicted)
• PSA: 12.89000
• Density: 1.488±0.06 g/cm3(Predicted)
• LogP: 3.30570

Purity/Quality:

98.5% ^*data from raw suppliers

5-bromo-3-methylisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-3-methyl-2-azanaphthalene

There total 2 articles about 5-Bromo-3-methyl-2-azanaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-methyl-isoquinolin-5-ylamine (54410-17-2) → 5-Brom-3-methyl-isochinolin (16552-67-3)

Guidance literature:

3-methyl-isoquinolin-5-ylamine; With hydrogen bromide; sodium nitrite; In water; at -5 - 0 ℃;

With hydrogen bromide; copper(I) bromide; In water; at 20 - 75 ℃;

Reference yield:

→ 5-Brom-3-methyl-isochinolin (16552-67-3)

Guidance literature:

5-Amino-3-methyl-isochinolin in wss. HBr, 1) wss. NaNO2 (0grad), 2) CuBr in konz. HBr (75grad);

Reference yield:

5-Brom-3-methyl-isochinolin (16552-67-3) + 2-chloro-propanoic acid, ethyl ester (535-13-7) → C15H17NO2 (1254715-70-2)

Guidance literature:

With manganese; (2,2'-bipyridine)nickel(II) dibromide; trifluoroacetic acid; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 16h;

upstream raw materials:

3-methyl-isoquinolin-5-ylamine

Downstream raw materials:

C₁₅H₁₇NO₂

Refernces

• 1、 -. "SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS". Page/Page column 139; 140. . Retrieved 2010/11/18.