1H-Benzimidazole-7-carboxylic acid, 2-butyl-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester

Base Information

• Chemical Name: 1H-Benzimidazole-7-carboxylic acid, 2-butyl-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester
• CAS No.: 167211-48-5
• Molecular Formula: C27H28N4O3
• Molecular Weight: 456.544
• Mol file: 167211-48-5.mol

Synonyms:

Chemical Property of 1H-Benzimidazole-7-carboxylic acid, 2-butyl-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester

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Technology Process of 1H-Benzimidazole-7-carboxylic acid, 2-butyl-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester

There total 1 articles about 1H-Benzimidazole-7-carboxylic acid, 2-butyl-1-[[2'-[(hydroxyamino)iminomethyl][1,1'-biphenyl]-4-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (136285-38-6) → 2-Butyl-3-[2'-(N-hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester (167211-48-5)

Guidance literature:

With hydroxylamine; In dimethyl sulfoxide; at 75 ℃; for 15h;

DOI:10.1021/jm960547h

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2-Butyl-3-[2'-(N-hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester (167211-48-5) → C29H30N4O4 (147404-83-9)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm960547h

Reference yield: 18.0%

2-Butyl-3-[2'-(N-hydroxycarbamimidoyl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester (167211-48-5) → 2-Butyl-3-[2'-(2-oxo-2,3-dihydro-2λ4-[1,2,3,5]oxathiadiazol-4-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

Guidance literature:

With pyridine; thionyl chloride; In tetrahydrofuran; dichloromethane; for 0.75h;

DOI:10.1021/jm960547h

upstream raw materials:

methyl 2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]benzimidazole-7-carboxylate

Downstream raw materials:

C₂₉H₃₀N₄O₄

2-Butyl-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]thiadiazol-3-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

2-Butyl-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

2-Butyl-3-[2'-(5-thioxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester

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