Technology Process of Carbamic acid, [(1R)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]-,
phenylmethyl ester
There total 1 articles about Carbamic acid, [(1R)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]-,
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; isobutyl chloroformate;
In
1,2-dimethoxyethane;
DOI:10.1021/jm020985q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine; trichlorophosphate / 1 h / 0 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 24 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C / Molecular sieve; Inert atmosphere
4: acetic acid; sodium cyanoborohydride / methanol / 60 h / 20 °C / Inert atmosphere
5: potassium carbonate / methanol / 0.5 h / 0 °C
With
pyridine; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; trifluoroacetic acid; trichlorophosphate;
In
1,4-dioxane; methanol; dichloromethane;
3: |Pictet-Spengler Synthesis;
DOI:10.1002/anie.202005748
