Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)-

Base Information

Chemical Name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)-
CAS No.:168163-00-6
Molecular Formula:C27H22F2N2O5
Molecular Weight:492.479
Hs Code.:
Mol file:168163-00-6.mol

Synonyms:

Suppliers and Price of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)-

There total 3 articles about Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-methoxybenzoyl)amino]benzoyl] -5H-1-benzazepin-5-ylidene]-, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 168162-76-3
methyl (Z)-[4,4-difluoro-1-[4-(2methoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

: 168163-00-6
(Z)-[4,4-difluoro-1-[4-(2-methoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 7h;
DOI:10.1248/cpb.51.1075

Reference yield:

: 579-75-9
2-Methoxybenzoic acid

: 168163-00-6
(Z)-[4,4-difluoro-1-[4-(2-methoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: pyridine / CH₂Cl₂ / 20 °C

3: 89 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1248/cpb.51.1075

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 168163-00-6
(Z)-[4,4-difluoro-1-[4-(2-methoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: 89 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1248/cpb.51.1075