Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[2-(1-methylethoxy)benzoyl]amino] benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

Base Information

Chemical Name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[2-(1-methylethoxy)benzoyl]amino] benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-
CAS No.:168163-02-8
Molecular Formula:C29H26F2N2O5
Molecular Weight:520.533
Hs Code.:
Mol file:168163-02-8.mol

Synonyms:

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Chemical Property of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[2-(1-methylethoxy)benzoyl]amino] benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

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Technology Process of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[2-(1-methylethoxy)benzoyl]amino] benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

There total 3 articles about Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[2-(1-methylethoxy)benzoyl]amino] benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 168162-78-5
methyl (Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

: 168163-02-8
(Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: With lithium hydroxide; In methanol; at 20 ℃; for 7h;
DOI:10.1248/cpb.51.1075

Reference yield:

: 63635-26-7
2-isopropoxybenzoic acid

: 168163-02-8
(Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: pyridine / CH₂Cl₂ / 20 °C

3: 75 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In methanol; dichloromethane;
DOI:10.1248/cpb.51.1075

Reference yield:

: 66849-11-4
2-(isopropoxy)benzoyl chloride

: 168163-02-8
(Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: 75 percent / aq. LiOH / methanol / 7 h / 20 °C

With pyridine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1248/cpb.51.1075