Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-thienyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

Base Information

Chemical Name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-thienyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-
CAS No.:168163-17-5
Molecular Formula:C25H20F2N2O4S
Molecular Weight:482.508
Hs Code.:
Mol file:168163-17-5.mol

Synonyms:

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Chemical Property of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-thienyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

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Technology Process of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-thienyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)-

There total 7 articles about Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-thienyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 168162-92-3
methyl (Z)-{4,4-difluoro-1-[4-(3-methylthiophene-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate

: 168163-17-5
(Z)-{4,4-difluoro-1-[4-(3-methylthiophene-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 7h;
DOI:10.1016/j.bmc.2005.10.035

Reference yield:

: 183171-54-2
methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

: 168163-17-5
(Z)-{4,4-difluoro-1-[4-(3-methylthiophene-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / CH₂Cl₂ / 12 h / 20 °C

2: 84 percent / SnCl₂ / ethyl acetate / 5 h / Heating

3: 90 percent / pyridine / acetonitrile / 8 h / 20 °C

4: 96 percent / NaOH / methanol / 7 h / 20 °C

With pyridine; sodium hydroxide; tin(ll) chloride; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2005.10.035

Reference yield:

: 183171-60-0
methyl (Z)-[4,4-difluoro-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

: 168163-17-5
(Z)-{4,4-difluoro-1-[4-(3-methylthiophene-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / SnCl₂ / ethyl acetate / 5 h / Heating

2: 90 percent / pyridine / acetonitrile / 8 h / 20 °C

3: 96 percent / NaOH / methanol / 7 h / 20 °C

With pyridine; sodium hydroxide; tin(ll) chloride; In methanol; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2005.10.035