Technology Process of 8-Hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid
There total 10 articles about 8-Hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
85589-24-8,94161-11-2,125226-84-8,125276-40-6,129171-41-1,129171-42-2,96790-35-1
8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acid
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at -40 ℃;
for 10h;
DOI:10.1016/S0040-4039(01)81539-2
-
-
85589-24-8,94161-11-2,125226-84-8,125276-40-6,129171-41-1,129171-42-2,96790-35-1
8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acid
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 76 percent / Jones reagent / 0 °C
2: 1.) C2H5MgBr; 2.) CuBr / 1.) THF, 0 deg C; 2.) 0 deg C for 15 min, reflux for 8 h.
4: 89 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / 23 °C
5: 99 percent / H2 / Lindlar / tetrahydrofuran / 0.75 h / 23 °C
6: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 °C
7: 92 percent / Jones reagens / 1.5 h / 23 °C
8: CHCl3 / 3 h / Heating
9: 1.) 1N aq.NaOH / 1.) chloroform, 23 grad C, 3 min; 2). benzene, 23 grad C, 10 h.
10: NaBH4 / methanol / 0.17 h / -40 °C
With
sodium hydroxide; sodium tetrahydroborate; jones reagent; Jones Reagens; ethylmagnesium bromide; hydrogen; 3-chloro-benzenecarboperoxoic acid; potassium bromide; copper(I) bromide;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; acetic acid;
DOI:10.1016/S0040-4039(01)81539-2
-
-
85589-24-8,94161-11-2,125226-84-8,125276-40-6,129171-41-1,129171-42-2,96790-35-1
8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acid
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) C2H5MgBr; 2.) CuBr / 1.) THF, 0 deg C; 2.) 0 deg C for 15 min, reflux for 8 h.
3: 89 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / 23 °C
4: 99 percent / H2 / Lindlar / tetrahydrofuran / 0.75 h / 23 °C
5: 99 percent / potassium bromide / tetrahydrofuran; aq. acetic acid / 10 h / 0 °C
6: 92 percent / Jones reagens / 1.5 h / 23 °C
7: CHCl3 / 3 h / Heating
8: 1.) 1N aq.NaOH / 1.) chloroform, 23 grad C, 3 min; 2). benzene, 23 grad C, 10 h.
9: NaBH4 / methanol / 0.17 h / -40 °C
With
sodium hydroxide; sodium tetrahydroborate; Jones Reagens; ethylmagnesium bromide; hydrogen; 3-chloro-benzenecarboperoxoic acid; potassium bromide; copper(I) bromide;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; acetic acid;
DOI:10.1016/S0040-4039(01)81539-2
