Benzenesulfonamide, N-[5-bromo-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]- 4-(1,1-dimethylethyl)-

Base Information

• Chemical Name: Benzenesulfonamide, N-[5-bromo-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]- 4-(1,1-dimethylethyl)-
• CAS No.: 169677-21-8
• Molecular Formula: C21H24BrN5O4S2
• Molecular Weight: 554.489
• Mol file: 169677-21-8.mol

Synonyms:

Chemical Property of Benzenesulfonamide, N-[5-bromo-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]- 4-(1,1-dimethylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfonamide, N-[5-bromo-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]- 4-(1,1-dimethylethyl)-

There total 7 articles about Benzenesulfonamide, N-[5-bromo-6-[2-[[5-(methylthio)-2-pyrimidinyl]oxy]ethoxy]-4-pyrimidinyl]- 4-(1,1-dimethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloro-5-(methylsulfanyl)pyrimidine (115581-36-7) + N-(5-bromo-6-(2-hydroxyethoxy)-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide (169677-48-9) → N-{5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide (169677-21-8)

Guidance literature:

N-(5-bromo-6-(2-hydroxyethoxy)-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide; With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 12h;

2-chloro-5-(methylsulfanyl)pyrimidine; In N,N-dimethyl acetamide; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/jm0102304

Reference yield:

4-tert-butylbenzenesulfonyl chloride (15084-51-2) + 5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]pyrimidine-4-amine → N-{5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide (169677-21-8)

Guidance literature:

With pyridine; In tetrahydrofuran;

Reference yield:

4-tert-butylbenzenesulfonyl chloride (15084-51-2) → N-{5-bromo-6-[2-(5-methylthiopyrimidin-2-yloxy)ethoxy]-pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide (169677-21-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 95 percent / NH₄OH / ethyl acetate / 1 h / 20 °C

2.1: 61 percent / NaH / dimethylsulfoxide / 2 h / 20 °C

3.1: NaH / 0.5 h / 20 °C

3.2: 88 percent / 20 h / 60 °C

4.1: 89 percent / NBS / dimethylformamide / 1 h / 20 °C

5.1: NaH / N,N-dimethyl-acetamide / 12 h / 20 °C

5.2: 84 percent / N,N-dimethyl-acetamide / 12 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; sodium hydride; In N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0102304

upstream raw materials:

2-chloro-5-(methylsulfanyl)pyrimidine

N-(5-bromo-6-(2-hydroxyethoxy)-4-pyrimidinyl)-4-tert-butylbenzenesulfonamide

4-tert-butylbenzenesulfonyl chloride

4-tert-butylbenzenesulphonamide

Downstream raw materials:

4-tert-butyl-N-(5-(4-diethoxymethyl)phenyl-6-(2-((5-methylthio-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)benzenesulfonamide

4-tert-butyl-N-(5-(4-formyl)phenyl-6-(2-((5-methylthio-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)benzenesulfonamide