2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol

Base Information

Chemical Name:2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol
CAS No.:169677-36-5
Molecular Formula:C13H15N3O2
Molecular Weight:245.281
Hs Code.:
DSSTox Substance ID:DTXSID80455877
Wikidata:Q82278030
Mol file:169677-36-5.mol

Synonyms:169677-36-5;2-{6-amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol;2-((6-Amino-5-(p-tolyl)pyrimidin-4-yl)oxy)ethanol;SCHEMBL4069241;DTXSID80455877;VYBWOLREYOQAKW-UHFFFAOYSA-N;2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol;2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

Suppliers and Price of 2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:245.116426730
Heavy Atom Count:18
Complexity:244

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=C(N=CN=C2OCCO)N

Technology Process of 2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol

There total 5 articles about 2-{6-Amino-5-(4-methylphenyl)-pyrimidin-4-yloxy}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 169677-74-1
4-amino-6-chloro-5-(4-methyl-phenyl)pyrimidine

: 169677-36-5
4-amino-6-(2-hydroxyethoxy)-5-(4-methylphenyl)pyrimidine

Guidance literature:: With ammonium chloride; In ethylene glycol;

Reference yield:

: 146533-43-9
4,6-dichloro-5-(4-methylphenyl)pyrimidine

: 169677-36-5
4-amino-6-(2-hydroxyethoxy)-5-(4-methylphenyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / 0.08 h / 0 °C

1.2: 91 percent / 2.5 h / 20 °C

2.1: 84 percent / NaN₃ / dimethylformamide / 19 h / 80 °C

3.1: 95 percent / H₂; H₂O / 10percent Pd/C / ethanol / 2 h / 20 °C

With sodium azide; water; hydrogen; sodium hydride; 10percent Pd/C; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0102304

Reference yield:

: 169677-44-5
4-chloro-6-(2-hydroxyethoxy)-5-(4-methylphenyl)pyrimidine

: 169677-36-5
4-amino-6-(2-hydroxyethoxy)-5-(4-methylphenyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NaN₃ / dimethylformamide / 19 h / 80 °C

2: 95 percent / H₂; H₂O / 10percent Pd/C / ethanol / 2 h / 20 °C

With sodium azide; water; hydrogen; 10percent Pd/C; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0102304