(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine

Base Information

Chemical Name:(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine
CAS No.:170151-28-7
Molecular Formula:C10H11F2N
Molecular Weight:183.2
Hs Code.:
DSSTox Substance ID:DTXSID10571034
Wikidata:Q82458609
Mol file:170151-28-7.mol

Synonyms:170151-28-7;(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine;SCHEMBL3316692;DTXSID10571034;AAXQLCRQEWZHDB-QMMMGPOBSA-N;(S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-ylamine

Suppliers and Price of (2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of (2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine

Chemical Property:

Boiling Point:242.4±40.0 °C(Predicted)
PKA:9.60±0.20(Predicted)
Density:1.203±0.06 g/cm3(Predicted)
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:183.08595568
Heavy Atom Count:13
Complexity:186

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(CC1N)C=C(C=C2F)F
Isomeric SMILES:C1CC2=C(C[C@H]1N)C=C(C=C2F)F

Technology Process of (2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine

There total 10 articles about (2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (S)-(-)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride

: 170151-28-7
(S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine

Guidance literature:: With sodium hydroxide; In water; pH=9;

Reference yield: 80.0%

: 173996-47-9
(R)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride

: 180914-87-8,170151-28-7
(R)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine

Guidance literature:: With sodium hydroxide; In water; pH=9;

Reference yield:

: C₁₂H₁₁F₂NO

: 170151-28-7
(S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: (+)-1,2-bis-(2R,5R)-2,5-(dimethylphospholan-1-yl)ethane; hydrogen / dichloromethane; ethylene glycol / 20 h / 40 - 50 °C / 7500.75 Torr

2: hydrogenchloride / ethanol / 24 h / 60 - 70 °C

3: sodium hydroxide / water / pH 9

With hydrogenchloride; hydrogen; (+)-1,2-bis-(2R,5R)-2,5-(dimethylphospholan-1-yl)ethane; sodium hydroxide; In ethanol; dichloromethane; water; ethylene glycol;