VITAMIN K1

Base Information

• Chemical Name: VITAMIN K1
• CAS No.: 12001-79-5
• Molecular Formula: C31H46O2
• Molecular Weight: 450.7
• Mol file: 12001-79-5.mol

Synonyms:Kanavit

Chemical Property of VITAMIN K1

Chemical Property:

• Vapor Pressure: 5.37E-12mmHg at 25°C
• Melting Point: −20 °C(lit.)
• Refractive Index: n20/D 1.527(lit.)
• Boiling Point: 546.4°Cat760mmHg
• Flash Point: 200.4°C
• PSA: 34.14000
• Density: 0.963g/cm³
• LogP: 9.15760
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

VITAMIN K 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Biological Functions: Both vitamins K3 and K4 may produce hyperbilirubinemia and kernicterus in neonates as well as hemolysis in neonates and glucose-6-phosphate–deficient patients. In fact, the only advantage of vitamins K3 and K4 over vitamin K1 is that whereas absorption of vitamin K1 requires the presence of bile, absorption of vitamins K3 and K4 does not, because they are absorbed via a passive process directly from the intestine. This may be a slight advantage for patients with cholestasis or severe pancreatic dysfunction. Only vitamin K1, however, is appropriate therapy for bleeding associated with warfarin and superwarfarin anticoagulation. Vitamin K2 is not used therapeutically.
• Clinical Use: Vitamin K1 (phytonadione, Mephyton) is the form of vitamin K most often used therapeutically. Vitamin K1 is safe for use in infants, pregnant women, and patients with glucose-6-phosphate deficiency.

Refernces

Synthesis and redox potentials of methylated vitamin K derivatives

10.1039/a900190e

Ralf Schmid, Friederike Goebel, André Warnecke, and Andreas Labahn study on the synthesis and redox potential measurements of various methylated vitamin K derivatives. The study aims to systematically vary the redox potentials of vitamin K derivatives by introducing different numbers of methyl groups in various positions to investigate their role in electron transfer reactions and structure-function relationships in vitamin K-dependent enzymes. The authors synthesized a range of vitamin K3, K1, and K2 derivatives with varying methyl substitutions and measured their redox potentials using cyclic voltammetry in DMF. They found that increasing the number of methyl substituents generally decreased the reduction potentials due to the electron-donating effect of alkyl groups. The study provides a wide range of reduction potentials for these derivatives, which are relevant for understanding electron transfer in photosynthetic reaction centers and for studying the binding affinity and steric properties of these compounds in biological systems.

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