1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)-

Base Information

Chemical Name:1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)-
CAS No.:171050-04-7
Molecular Formula:C18H24N2O5
Molecular Weight:348.399
Hs Code.:
Mol file:171050-04-7.mol

Synonyms:

Suppliers and Price of 1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)-

There total 1 articles about 1H-1,4-Benzodiazepine-2-acetic acid, 7-[(1,1-dimethylethoxy)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo-, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 171050-03-6
t-butyl (S)-4-fluoro-3-[[[4-methoxy-1,4-dioxo-2-aminobutyl]methylamino]methyl]benzoate

: 4-Fluoro-3-{[((E)-3-methoxycarbonyl-acryloyl)-methyl-amino]-methyl}-benzoic acid tert-butyl ester

: 171050-04-7
(S)-2-methoxycarbonylmethyl-4-methyl-3-exo-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]diazepine-7-carboxylic acid tert-butyl ester

Guidance literature:: In dimethyl sulfoxide; at 125 ℃; for 18h;
DOI:10.1016/0040-4039(95)02054-3

Reference yield:

: 171050-04-7
(S)-2-methoxycarbonylmethyl-4-methyl-3-exo-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]diazepine-7-carboxylic acid tert-butyl ester

: 171049-14-2
lotrafiban

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / methoxybenzene; CH₂Cl₂ / 3 h / 20 °C

2: 143 mg / EDCI; HOBt / CH₂Cl₂ / 1 h / 20 °C

3: 79 mg / aq. NaOH / methanol / 10 h / Heating

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; methoxybenzene;
DOI:10.1021/ol016258r