7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one

Base Information

Chemical Name:7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one
CAS No.:171178-37-3
Molecular Formula:C7H4FN3O
Molecular Weight:165.127
Hs Code.:2933990090
Mol file:171178-37-3.mol

Synonyms:7-fluoro-4-oxo-3H-pyrido[4,3-d]pyrimidine;7-Fluoropyrido[4,3-d]pyrimidin-4-ol;InChI=1/C7H4FN3O/c8-6-1-5-4(2-9-6)7(12)11-3-10-5/h1-3H,(H,10,11,12);Pyrido[4,3-d]pyrimidin-4(1H)-one,7-fluoro;LWRUMQJSJBZUCC-UHFFFAOYSA;

Suppliers and Price of 7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alichem
7-Fluoropyrido[4,3-d]pyrimidin-4(1H)-one
5g
$ 4310.25

Alichem
7-Fluoropyrido[4,3-d]pyrimidin-4(1H)-one
1g
$ 1577.18

Total 2 raw suppliers

Chemical Property of 7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one

Chemical Property:

PSA：58.90000
LogP:0.86950

Purity/Quality:

99.90% ^*data from raw suppliers

7-Fluoropyrido[4,3-d]pyrimidin-4(1H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one

There total 3 articles about 7-Fluoropyrido[4,3-d]pyriMidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 171178-36-2
7-aminopyrido<4,3-d>pyrimidin-4(3H)-one

: 171178-37-3
7-fluoro-4-oxo-3H-pyrido[4,3-d]pyrimidine

Guidance literature:: With tetrafluoroboric acid; sodium nitrite; 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h;
DOI:10.1021/jm9508651

Reference yield:

: 75776-47-5
2,4-diamino-5-cyanopyridine

: 171178-37-3
7-fluoro-4-oxo-3H-pyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 90percent H₂SO₄ / 3 h / 60 - 70 °C

2: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min

3: 57 percent / 50percent HBF₄, NaNO₂ / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h

With sodium hydroxide; tetrafluoroboric acid; sulfuric acid; sodium nitrite;
DOI:10.1021/jm9508651

Reference yield:

: 171178-35-1
4,6-diaminopyridine-3-carboxamide

: 171178-37-3
7-fluoro-4-oxo-3H-pyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min

2: 57 percent / 50percent HBF₄, NaNO₂ / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h

With sodium hydroxide; tetrafluoroboric acid; sodium nitrite;
DOI:10.1021/jm9508651