5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE

Base Information

• Chemical Name: 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE
• CAS No.: 172498-89-4
• Molecular Formula: C23H20N2O
• Molecular Weight: 340.425
• Hs Code.: 2933290090
• Mol file: 172498-89-4.mol

Synonyms:5-Hydroxylmethyl-1-N-trityl-imidazole;5-Hydroxymethyl-1-triphenylmethyl-imidazole;

Chemical Property of 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE

Chemical Property:

• Vapor Pressure: 1.77E-11mmHg at 25°C
• Boiling Point: 516.1oC at 760 mmHg
• Flash Point: 265.9oC
• PSA: 38.05000
• Density: 1.1g/cm3
• LogP: 4.21560

Purity/Quality:

98%min ^*data from raw suppliers

(1-Trityl-1H-imidazol-5-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE

There total 1 articles about 5-HYDROXYLMETHYL-1-N-TRITYL-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1H-imidazol-4-yl)methanol (822-55-9) + trityl chloride (76-83-5) → (1-trityl-1H-imidazol-5-yl)-methanol (172498-89-4)

Guidance literature:

With triethylamine; In N-methyl-acetamide; N,N-dimethyl-formamide;

Reference yield: 61.1%

(Z)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione + (1-trityl-1H-imidazol-5-yl)-methanol (172498-89-4) → C35H29N3O3S (1438409-81-4)

Guidance literature:

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 45 ℃;

DOI:10.1039/c3ob40199e

Reference yield:

(1-trityl-1H-imidazol-5-yl)-methanol (172498-89-4) → 1-trityl-4-benzoylthiomethylimidazole (339162-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: 75 percent / t-BuOK / dimethylformamide

With potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1: esterification / 2: substitution;

DOI:10.1016/S0968-0896(00)00266-2

upstream raw materials:

(1H-imidazol-4-yl)methanol

trityl chloride

Downstream raw materials:

1-trityl-4-benzoylthiomethylimidazole

diphenylmethyl 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-[(3-tritylimidazol-4-yl)methylthio]-3-cephem-4-carboxylate

C₃₅H₂₉N₃O₃S

Refernces