Dexamethasone valerate

Base Information

• Chemical Name: Dexamethasone valerate
• CAS No.: 33755-46-3
• Molecular Formula: C₂₇H₃₇FO₆
• Molecular Weight: 476.586
• European Community (EC) Number: 251-669-2
• UNII: OI7CP949NN
• DSSTox Substance ID: DTXSID3022904
• Nikkaji Number: J67.028F
• Wikidata: Q27285667
• ChEMBL ID: CHEMBL1378167
• Mol file: 33755-46-3.mol

Synonyms:dexamethasone 17-valerate;dexamethasone valerate

Chemical Property of Dexamethasone valerate

Chemical Property:

• Vapor Pressure: 7.72E-17mmHg at 25°C
• Boiling Point: 607.5 °C at 760 mmHg
• Flash Point: 321.2 °C
• PSA: 100.90000
• Density: 1.24 g/cm³
• LogP: 3.63680
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 476.25741706
• Heavy Atom Count: 34
• Complexity: 957

Purity/Quality:

98%,99%, ^*data from raw suppliers

DexamethasoneValerate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO
• Isomeric SMILES: CCCCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO
• Uses: Dexamethasone Valerate (Betamethasone Valerate EP Impurity C) is an impurity of Dexamethasone (D298800), which is a glucocorticoid that is used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
• Therapeutic Function: Corticosteroid

Technology Process of Dexamethasone valerate

There total 4 articles about Dexamethasone valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Betamethason-17-valerianat (2152-44-5,33755-46-3)

Guidance literature:

Betamethason-17,21-divalerianat, H2SO4 aq. / MeOH;

Reference yield:

→ betamethasone 17-valerate (2152-44-5,33755-46-3)

Guidance literature:

Betamethason-17,21-methylorthovalerianat, HCl, H2O;

Reference yield:

→ Dexamethason-17-valerat (2152-44-5,33755-46-3)

Guidance literature:

II, saure Hydrolyse;