5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde

Base Information

• Chemical Name: 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde
• CAS No.: 17288-50-5
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 29339900
• DSSTox Substance ID: DTXSID70570886
• Wikidata: Q82458452
• Mol file: 17288-50-5.mol

Synonyms:5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde;17288-50-5;5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxaldehyde;5-Methoxy-4-azaindole-2-carbaldehyde;MFCD08448191;SCHEMBL1788955;DTXSID70570886;AMY24510;AC4708;AKOS006288929;SY246189;CS-0131084;J-517668

Chemical Property of 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 1.82E-05mmHg at 25°C
• Boiling Point: 363.3oC at 760 mmHg
• Flash Point: 173.5oC
• PSA: 54.98000
• Density: 1.347g/cm3
• LogP: 1.38400
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 176.058577502
• Heavy Atom Count: 13
• Complexity: 198

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC2=C(C=C1)NC(=C2)C=O

Technology Process of 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde

There total 1 articles about 5-Methoxy-1H-pyrrolo[3,2-b]pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-formyl-5-methoxy-4-azaindole (17288-50-5)

Guidance literature:

2-Hydroxymethyl-5-methoxy-4-azaindol, MnO2;

DOI:10.1021/jo01274a017

Reference yield:

4-Bromodiphenyl ether (101-55-3) + 2-formyl-5-methoxy-4-azaindole (17288-50-5) → C21H18N2O3 (1310720-68-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -10 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.01.012

Reference yield:

2-formyl-5-methoxy-4-azaindole (17288-50-5) → C20H14N2O3 (1282035-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / 2 h / -10 °C

2: manganese(IV) oxide / chloroform / 1 h / 20 °C

3: boron tribromide / dichloromethane / 6 h / 20 °C

With manganese(IV) oxide; n-butyllithium; boron tribromide; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2011.01.012

Downstream raw materials:

5-methoxy-2-vinyl-4-azaindole

C₂₁H₁₈N₂O₃

C₂₀H₁₄N₂O₃

C₂₁H₁₆N₂O₃