Technology Process of Phosphine oxide, (1-methylheptyl)diphenyl-, (R)-
There total 8 articles about Phosphine oxide, (1-methylheptyl)diphenyl-, (R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-hexene; C14H14BrOP;
With
potassium phosphate; nickel(II) bromide 2-methoxyethyl ether complex; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole);
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
trimethoxysilane;
In
N,N-dimethyl acetamide; 1,2-dichloro-ethane;
at 0 - 18 ℃;
for 12h;
enantioselective reaction;
DOI:10.1021/jacs.9b09415
- Guidance literature:
-
Multi-step reaction with 2 steps
1: BuLi / tetrahydrofuran; hexane / 1.) -30 deg C, 4 h, 2.) 0 deg C, 30 min
2: H2O2 / tetrahydrofuran; hexane
With
n-butyllithium; dihydrogen peroxide;
In
tetrahydrofuran; hexane;
DOI:10.1039/p19960002567
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: phosphorus tribromide / dichloromethane / 0 - 20 °C
2.1: nickel(II) bromide 2-methoxyethyl ether complex; potassium phosphate; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole) / 1,2-dichloro-ethane; N,N-dimethyl acetamide / 0.17 h / 0 °C / Inert atmosphere
2.2: 12 h / 0 - 18 °C
With
potassium phosphate; nickel(II) bromide 2-methoxyethyl ether complex; (4S,4'S)-2,2'-(1-phenylpropane-2,2-diyl)bis(4,5,5-triphenyl-4,5-dihydrooxazole); phosphorus tribromide;
In
dichloromethane; N,N-dimethyl acetamide; 1,2-dichloro-ethane;
DOI:10.1021/jacs.9b09415
