sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate

Base Information

Chemical Name:sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate
CAS No.:101641-82-1
Molecular Formula:C₂₀H₃₀FO₅*Na
Molecular Weight:392.443
Hs Code.:
Mol file:101641-82-1.mol

sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate

Synonyms:4H-Cyclopenta[b]furan,prosta-6,13-dien-1-oic acid deriv.; SC 39902

Suppliers and Price of sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate

Chemical Property:

Vapor Pressure:2.27E-13mmHg at 25°C
Boiling Point:528.4°C at 760 mmHg
Flash Point:273.4°C

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate

There total 13 articles about sodium (5R)-5-fluoro-5-{(3aS,4R,5R,6aS)-5-hydroxy-4-[(1Z,3S)-3-hydroxyoct-1-en-1-yl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl}pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33854-16-9
(+)-prostaglandin F_2α

: 101641-82-1
6,9α-epoxy-5(S)-fluoro-11α,15(S)-dihydroxyprosta-6,13(E)-dien-1-oic acid, sodium salt

Guidance literature:: Multi-step reaction with 5 steps

2: 13 percent / K₂CO₃, FClO₃ / 15 - 20 °C

3: 80 percent / 2-picoline, magnesium triflate / xylene / 2 h / Heating

4: 88 percent / 1 M Bu₄NF / tetrahydrofuran / 0.25 h / Ambient temperature

5: 263 mg / 1 N aq. NaOH / methanol / Ambient temperature

With α-picoline; sodium hydroxide; perchloryl fluoride; tetrabutyl ammonium fluoride; potassium carbonate; magnesium triflate; In tetrahydrofuran; methanol; xylene;
DOI:10.1021/jo00382a003

Reference yield:

: 105604-42-0
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxyprosta-5(Z),13(E)-dien-1-oate

: 101641-82-1
6,9α-epoxy-5(S)-fluoro-11α,15(S)-dihydroxyprosta-6,13(E)-dien-1-oic acid, sodium salt

Guidance literature:: Multi-step reaction with 4 steps

1: 23 percent / K₂CO₃, FClO₃

2: 74 percent / 2,6-lutidine, magnesium triflate, tert-butyltoluene / 0.17 h / Heating

3: 98 percent / 1 M Bu₄NF / tetrahydrofuran / 22 h / Ambient temperature

4: 263 mg / 1 N aq. NaOH / methanol / Ambient temperature

With 2,6-dimethylpyridine; sodium hydroxide; perchloryl fluoride; tetrabutyl ammonium fluoride; potassium carbonate; magnesium triflate; In tetrahydrofuran; methanol;
DOI:10.1021/jo00382a003

Reference yield:

: 107097-94-9,107097-95-0
methyl 11α,15(S)-bis<<(1,1-dimethylethyl)diphenylsilyl>oxy>-6,9α-epoxy-6-methoxyprost-13(E)-en-1-oate

: 101641-82-1
6,9α-epoxy-5(S)-fluoro-11α,15(S)-dihydroxyprosta-6,13(E)-dien-1-oic acid, sodium salt

Guidance literature:: Multi-step reaction with 5 steps

1: 2-picoline, magnesium triflate / toluene / 1 h / Heating

2: 23 percent / K₂CO₃, FClO₃

3: 74 percent / 2,6-lutidine, magnesium triflate, tert-butyltoluene / 0.17 h / Heating

4: 98 percent / 1 M Bu₄NF / tetrahydrofuran / 22 h / Ambient temperature

5: 263 mg / 1 N aq. NaOH / methanol / Ambient temperature

With α-picoline; 2,6-dimethylpyridine; sodium hydroxide; perchloryl fluoride; tetrabutyl ammonium fluoride; potassium carbonate; magnesium triflate; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jo00382a003