Technology Process of D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-
There total 16 articles about D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
water; tert-butyl alcohol;
at 0 ℃;
for 0.5h;
DOI:10.1021/ja003835i
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaBH4 / methanol
2: PBr3 / diethyl ether
3: 80 percent / N-benzylcinchoninium bromide, 50 percent aq. NaOH
4: methanolic HCl
5: SOCl2
6: NaHCO3 / tetrahydrofuran
7: K2CO3 / methanol; H2O
With
hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; N-benzylcinchoninium bromide; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate;
In
tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1016/0040-4039(96)00459-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / n-BuLi; CuCN
2: 87 percent / TFA
3: 82 percent / NaHCO3 / CH2Cl2 / 16 h / 25 °C
4: 100 percent / LiOH*H2O / H2O; 2-methyl-propan-2-ol / 0.5 h / 0 °C
With
lithium hydroxide; n-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid;
In
dichloromethane; water; tert-butyl alcohol;
1: Schollkopf alkylation;
DOI:10.1021/ja003835i