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D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-

Base Information Edit
  • Chemical Name:D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-
  • CAS No.:173775-54-7
  • Molecular Formula:C14H17FN2O6
  • Molecular Weight:328.297
  • Hs Code.:
  • DSSTox Substance ID:DTXSID80455973
  • Nikkaji Number:J1.360.165H
  • Wikidata:Q82278153
  • Mol file:173775-54-7.mol
D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-

Synonyms:D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-;173775-54-7;DTXSID80455973;N-boc-4-fluoro-3-nitro-d-phenylalanine;N-(tert-Butoxycarbonyl)-3-nitro-4-fluoro-D-phenylalanine

Suppliers and Price of D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 1 raw suppliers
Chemical Property of D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro- Edit
Chemical Property:
  • XLogP3:2.4
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:6
  • Exact Mass:328.10706443
  • Heavy Atom Count:23
  • Complexity:459
Purity/Quality:

99.90% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC(=C(C=C1)F)[N+](=O)[O-])C(=O)O
  • Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)F)[N+](=O)[O-])C(=O)O
Technology Process of D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro-

There total 16 articles about D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-fluoro-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With lithium hydroxide; In water; tert-butyl alcohol; at 0 ℃; for 0.5h;
DOI:10.1021/ja003835i
Guidance literature:
Multi-step reaction with 7 steps
1: NaBH4 / methanol
2: PBr3 / diethyl ether
3: 80 percent / N-benzylcinchoninium bromide, 50 percent aq. NaOH
4: methanolic HCl
5: SOCl2
6: NaHCO3 / tetrahydrofuran
7: K2CO3 / methanol; H2O
With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; N-benzylcinchoninium bromide; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1016/0040-4039(96)00459-5
Guidance literature:
Multi-step reaction with 4 steps
1: 80 percent / n-BuLi; CuCN
2: 87 percent / TFA
3: 82 percent / NaHCO3 / CH2Cl2 / 16 h / 25 °C
4: 100 percent / LiOH*H2O / H2O; 2-methyl-propan-2-ol / 0.5 h / 0 °C
With lithium hydroxide; n-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; water; tert-butyl alcohol; 1: Schollkopf alkylation;
DOI:10.1021/ja003835i
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