Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b] thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans-

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Chemical Name:Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b] thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans-
CAS No.:174475-53-7
Molecular Formula:C35H49NO4SSi
Molecular Weight:607.93
Hs Code.:

Methanone,
[2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b]
thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans-

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Chemical Property of Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b] thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans-

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Technology Process of Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b] thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans-

There total 5 articles about Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-6-methoxybenzo[b] thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: trans-4-[(tert-butylydimethylsilyl)oxy]cyclohexylmagnesium bromide

: 165742-76-7
[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

: 174475-53-7
{2-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-6-methoxy-benzo[b]thiophen-3-yl}-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1021/jm9606352

Reference yield:

: 32388-22-0
trans-1,4-bromohydroxycyclohexane

: 174475-53-7
{2-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-6-methoxy-benzo[b]thiophen-3-yl}-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: 1.) Mg / 1.) THF, 2.) THF

With 1H-imidazole; magnesium; In N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(95)00575-E

Reference yield:

: 111359-29-6
6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine

: 174475-53-7
{2-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-6-methoxy-benzo[b]thiophen-3-yl}-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / chlorobenzene / 9 h / 100 - 105 °C

2: 53 percent / tetrahydrofuran / 1.5 h / Ambient temperature

In tetrahydrofuran; chlorobenzene;
DOI:10.1021/jm9606352