Englitazone

Base Information

• Chemical Name: Englitazone
• CAS No.: 109229-58-5
• Deprecated CAS: 122228-35-7,109208-77-7,109208-78-8
• Molecular Formula: C20H19 N O3 S
• Molecular Weight: 353.442
• Hs Code.: 2934999090
• UNII: ZQW5577C3O
• Nikkaji Number: J360.937E
• NCI Thesaurus Code: C83688
• Metabolomics Workbench ID: 144606
• ChEMBL ID: CHEMBL17669
• Mol file: 109229-58-5.mol

Synonyms:5-((3,4-dihydro-2-phenylmethyl-2H-1-benzopyran-6-yl)methyl)thiazolidine-2,4-dione;CP 68722;CP 72466;CP 72467;CP-68722;CP-72466;CP-72467;englitazone

Chemical Property of Englitazone

Chemical Property:

• Vapor Pressure: 1.09E-12mmHg at 25°C
• Refractive Index: 1.638
• Boiling Point: 562.7°Cat760mmHg
• PKA: 6.33±0.50(Predicted)
• Flash Point: 294.1°C
• PSA: 71.91000
• Density: 1.3g/cm³
• LogP: 3.63160
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 353.10856464
• Heavy Atom Count: 25
• Complexity: 505

Purity/Quality:

98%min ^*data from raw suppliers

ENGLITAZONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=CC(=C2)CC3C(=O)NC(=O)S3)OC1CC4=CC=CC=C4
• Isomeric SMILES: C1CC2=C(C=CC(=C2)CC3C(=O)NC(=O)S3)O[C@H]1CC4=CC=CC=C4
• Uses: Antidiabetic.

Technology Process of Englitazone

There total 8 articles about Englitazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

5-[1-((R)-2-Benzyl-chroman-6-yl)-meth-(E)-ylidene]-thiazolidine-2,4-dione (109208-74-4,109208-75-5,109229-59-6) → englitazone (109229-58-5,122228-35-7,142696-28-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00105a050

Reference yield: 65.0%

5-[1-((S)-2-Benzyl-chroman-6-yl)-meth-(E)-ylidene]-thiazolidine-2,4-dione (109208-74-4,109208-75-5,109229-59-6) → 5-((S)-2-Benzyl-chroman-6-ylmethyl)-thiazolidine-2,4-dione (109229-58-5,122228-35-7,142696-28-4)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00105a050

Reference yield: 57.0%

5-<(2-benzyl-3,4-dihydro-2H-1-benzopyran-6-yl)methylene>thiazolidine-2,4-dione (109208-74-4,109208-75-5,109229-59-6) → englitazone (109229-58-5)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00105a050

upstream raw materials:

5-<(2-benzyl-3,4-dihydro-2H-1-benzopyran-6-yl)methylene>thiazolidine-2,4-dione

2-benzyl-6-formyl-3,4-dihydro-2H-1-benzopyran

5-[1-((S)-2-Benzyl-chroman-6-yl)-meth-(E)-ylidene]-thiazolidine-2,4-dione

(2S)-benzyl-6-(formyl)-2,3-dihydro-4H-benzopyran

Downstream raw materials:

englitazone