Benzoic acid, 2,6-dichloro-, (3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester

Base Information

Chemical Name:Benzoic acid, 2,6-dichloro-, (3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester
CAS No.:175211-07-1
Molecular Formula:C₃₉H₃₉Cl₂N₃O₈
Molecular Weight:748.66
Hs Code.:

Benzoic acid, 2,6-dichloro-,
(3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop
yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester

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Chemical Property of Benzoic acid, 2,6-dichloro-, (3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester

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Technology Process of Benzoic acid, 2,6-dichloro-, (3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester

There total 5 articles about Benzoic acid, 2,6-dichloro-, (3S)-5-(1,1-dimethylethoxy)-2,5-dioxo-3-[[[2-oxo-3-[(1-oxo-3-phenylprop yl)amino]-6-(phenylmethyl)-1(2H)-pyridinyl]acetyl]amino]pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147269-28-1
6-benzyl-3(benzyloxycarbonylamino) pyrid-2-one

: 175211-07-1
2,6-Dichloro-benzoic acid (S)-3-{2-[6-benzyl-2-oxo-3-(3-phenyl-propionylamino)-2H-pyridin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran

2: H₂ / Pd/C / methanol

3: NaHCO₃ / dioxane

4: aq. NaOH / methanol

5: 1.) HOBt, EDC, 2.) (Ph₃)2PdCl₂, Bu₃SnH / 1.) 25 min, 2.) THF

With sodium hydroxide; (Ph₃)2PdCl₂; hydrogen; tri-n-butyl-tin hydride; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/S0960-894X(97)00394-6

Reference yield:

: 175210-53-4
methyl [6-benzyl-3-benzyloxycarbonylamino-1,2-dihydro-2-oxo-1-pyridyl]-acetate

: 175211-07-1
2,6-Dichloro-benzoic acid (S)-3-{2-[6-benzyl-2-oxo-3-(3-phenyl-propionylamino)-2H-pyridin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol

2: NaHCO₃ / dioxane

3: aq. NaOH / methanol

4: 1.) HOBt, EDC, 2.) (Ph₃)2PdCl₂, Bu₃SnH / 1.) 25 min, 2.) THF

With sodium hydroxide; (Ph₃)2PdCl₂; hydrogen; tri-n-butyl-tin hydride; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1016/S0960-894X(97)00394-6

Reference yield:

: 175210-62-5
methyl [3-amino-6-benzyl-1,2-dihydro-2-oxo-1-pyridyl]acetate

: 175211-07-1
2,6-Dichloro-benzoic acid (S)-3-{2-[6-benzyl-2-oxo-3-(3-phenyl-propionylamino)-2H-pyridin-1-yl]-acetylamino}-4-tert-butoxycarbonyl-2-oxo-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / dioxane

2: aq. NaOH / methanol

3: 1.) HOBt, EDC, 2.) (Ph₃)2PdCl₂, Bu₃SnH / 1.) 25 min, 2.) THF

With sodium hydroxide; (Ph₃)2PdCl₂; tri-n-butyl-tin hydride; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; methanol;
DOI:10.1016/S0960-894X(97)00394-6