2-Fluorocyclooctan-1-one

Base Information

Chemical Name:2-Fluorocyclooctan-1-one
CAS No.:1755-14-2
Molecular Formula:C8H13FO
Molecular Weight:144.189
Hs Code.:
DSSTox Substance ID:DTXSID70506206
Nikkaji Number:J733.547D

Synonyms:2-fluorocyclooctanone;2-Fluorocyclooctan-1-one;1755-14-2;SCHEMBL2386257;DTXSID70506206;ZOQWAFBZFAIXHE-UHFFFAOYSA-N

Suppliers and Price of 2-Fluorocyclooctan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 2-Fluorocyclooctan-1-one

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:144.095043196
Heavy Atom Count:10
Complexity:122

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCCC(=O)C(CC1)F

Technology Process of 2-Fluorocyclooctan-1-one

There total 1 articles about 2-Fluorocyclooctan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14478-13-8
1-cyclooctenyl acetate

: 502-49-8
cycloactanone

: 1755-14-2
α-fluorocycloctanone

Guidance literature:: With xenon difluoride; hydrogen fluoride; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1039/c39800000759

Reference yield:

: 1755-14-2
α-fluorocycloctanone

: 4-(1-fluoro-cyclooct-2-ynylmethyl)benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 3 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0 °C

With potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; toluene;

Reference yield:

: 1755-14-2
α-fluorocycloctanone

: 4-(1-fluoro-2-trifluoromethanesulfonyloxy-cyclooct-2-enylmethyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 3 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

With potassium hexamethylsilazane; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; toluene;