cis-Terbinafine Hydrochloride

Base Information

• Chemical Name: cis-Terbinafine Hydrochloride
• CAS No.: 176168-78-8
• Molecular Formula: C₂₁H₂₅N*ClH
• Molecular Weight: 327.897
• Hs Code.: 2921490002
• Mol file: 176168-78-8.mol

Synonyms:UNII-2H771UZ786;Terbinafine related compound B;cis-Terbinafine Hydrochloride;

Chemical Property of cis-Terbinafine Hydrochloride

Chemical Property:

• Melting Point: 135 °C(Solv: ethyl acetate (141-78-6))
• PSA: 3.24000
• LogP: 5.67930

Purity/Quality:

99%+, ^*data from raw suppliers

cis-TerbinafineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity in the production of Terbinafine hydrochloride.

Technology Process of cis-Terbinafine Hydrochloride

There total 17 articles about cis-Terbinafine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methyl-1-naphthalenemethylamine (14489-75-9) + 1-chloro-6,6-dimethyl-hept-2-ene-4-yn (287471-30-1) → terbinafine hydrochloride (78628-80-5,176168-78-8)

Guidance literature:

N-methyl-1-naphthalenemethylamine; 1-chloro-6,6-dimethyl-hept-2-ene-4-yn; With potassium carbonate; In water; at 80 ℃; for 4h; Large scale;

With hydrogenchloride; In water; at 0 - 10 ℃; Large scale;

Reference yield: 89.0%

→ terbinafine hydrochloride (78628-80-5,176168-78-8)

Guidance literature:

Reference yield: 82.6%

N-(3-chloroallyl)-1-methyl-1-naphthylmethylamine (387383-30-4) + 3,3-Dimethylbut-1-yne (917-92-0) → terbinafine hydrochloride (78628-80-5,176168-78-8)

Guidance literature:

N-(3-chloroallyl)-1-methyl-1-naphthylmethylamine; 3,3-Dimethylbut-1-yne; With copper(l) iodide; N-butylamine; triphenylphosphine; palladium dichloride; at 60 - 65 ℃; for 20h;

With hydrogenchloride; In water; at 85 - 90 ℃; for 0.5h; Temperature;

upstream raw materials:

terbinafin

N-methyl-1-naphthalenemethylamine hydrochloride

(Z)-1-chloro-6,6-dimethylhept-2-en-4-yne

1-chloro-6,6-dimethyl-hept-2-ene-4-yn

Refernces

• 1、 -. "Preparation method for improving purity of terbinafine hydrochloride". Paragraph 0023-0037. . Retrieved 2019/11/21.
• 2、 -. "PROCESS FOR PREPARING TERBINAFINE". Page/Page column 17; 18. . Retrieved 2010/11/27.