2-Azaspiro[4.5]decane

Base Information

• Chemical Name: 2-Azaspiro[4.5]decane
• CAS No.: 176-66-9
• Molecular Formula: C9H17N
• Molecular Weight: 139.241
• Hs Code.: 2933990090
• European Community (EC) Number: 823-346-1
• DSSTox Substance ID: DTXSID60329249
• Nikkaji Number: J2.747.207I
• Wikidata: Q82092430
• Mol file: 176-66-9.mol

Synonyms:2-Azaspiro[4.5]decane;176-66-9;2-Aza-spiro[4.5]decane;2-azaspiro[4,5]decane;MFCD06656114;3-azaspiro[4.5]decane;EC-000.1874;SCHEMBL1372723;DTXSID60329249;AKOS005146221;PB15836;BS-13315;SY065554;CS-0054644;FT-0683705;EN300-88775;P10367;A881507;F2148-0040;Z979421238

Chemical Property of 2-Azaspiro[4.5]decane

Chemical Property:

• Vapor Pressure: 0.247mmHg at 25°C
• Boiling Point: 205.7oC at 760 mmHg
• Flash Point: 72.7oC
• PSA: 12.03000
• Density: 0.94g/cm3
• LogP: 2.25900
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 139.136099547
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

97% ^*data from raw suppliers

2-Azaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2(CC1)CCNC2

Technology Process of 2-Azaspiro[4.5]decane

There total 4 articles about 2-Azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azaspiro[4.5]decan-1-one (1005-85-2) → 2-azaspiro[4.5]decane (176-66-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Heating / reflux;

Reference yield:

gabapentin-lactam (64744-50-9) → 2-azaspiro[4.5]decane (176-66-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux; Inert atmosphere;

Reference yield:

2-methyl-2-(2-azaspiro[4.5]decan-2-yl)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propenamide → 2-azaspiro[4.5]decane (176-66-9)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; triethylamine; In methanol;

DOI:10.1021/acs.joc.0c00870

upstream raw materials:

2-azaspiro[4.5]decan-1-one

gabapentin-lactam

Downstream raw materials:

(R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-benzyloxycarbonylamino-5-oxo-pentanoic acid benzyl ester

(R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-(3-chloro-benzoylamino)-5-oxo-pentanoic acid

(R)-5-(2-Aza-spiro[4.5]dec-2-yl)-4-(3,5-dichloro-benzoylamino)-5-oxo-pentanoic acid

2-azoniaspiro[4.5]decane hydrochloride