(2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol

Base Information

Chemical Name:(2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol
CAS No.:176700-45-1
Molecular Formula:C9H12ClNO2
Molecular Weight:201.653
Hs Code.:
DSSTox Substance ID:DTXSID40365908
Wikidata:Q82150943

Synonyms:176700-45-1;AC1M1GDQ;SCHEMBL8799683;DTXSID40365908;MFCD24624118;(S)-1-Amino-3-(4-chlorophenoxy)-2-propanol

Suppliers and Price of (2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:201.0556563
Heavy Atom Count:13
Complexity:138

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1OCC(CN)O)Cl
Isomeric SMILES:C1=CC(=CC=C1OC[C@H](CN)O)Cl

Technology Process of (2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol

There total 5 articles about (2S)-1-amino-3-(4-chlorophenoxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 106-48-9,82344-39-6
4-chloro-phenol

: 176700-45-1
(S)-2-hydroxy-3-(p-chlorophenoxy)propylamine

Guidance literature:: (S)-epichlorohydrin; 4-chloro-phenol; With potassium carbonate; at 110 ℃; Heating;

With ammonia; at 20 ℃; for 24h;
DOI:10.1002/chir.22089

Reference yield: 75.0%

: 351465-58-2
(S)-1-(4-Chloro-phenoxy)-3-(trityl-amino)-propan-2-ol

: 176700-45-1
(S)-2-hydroxy-3-(p-chlorophenoxy)propylamine

Guidance literature:: With trifluoroacetic acid; In methanol; dichloromethane; at 20 ℃;
DOI:10.1021/jo010239d

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 176700-45-1
(S)-2-hydroxy-3-(p-chlorophenoxy)propylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / NaH / dimethylformamide

2: 75 percent / propan-2-ol / 24 h / Heating

3: 75 percent / TFA / CH₂Cl₂; methanol / 20 °C

With sodium hydride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo010239d