METHYL 2-(CHLOROMETHYL)NICOTINATE

Base Information

• Chemical Name: METHYL 2-(CHLOROMETHYL)NICOTINATE
• CAS No.: 177785-14-7
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol file: 177785-14-7.mol

Synonyms:

Chemical Property of METHYL 2-(CHLOROMETHYL)NICOTINATE

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(chloromethyl)nicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-(chloromethyl)nicotinate is an intermediate used in synthesizing NAI 1 (N215005), which is used in the process of visualizing the physical basis for molecular behavious inside living cells. RNAs are central to biological regulation and this molecule aids in the first global view of RNA secondary structures in living cells for all four bases.

Technology Process of METHYL 2-(CHLOROMETHYL)NICOTINATE

There total 6 articles about METHYL 2-(CHLOROMETHYL)NICOTINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 2-methylnicotinate (65719-09-7) → 2-chloromethyl-pyridine-3-carboxylic acid methyl ester (177785-14-7)

Guidance literature:

With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.0c12246

Reference yield:

methyl 2-methyl-1-oxo-1lambda5-pyridine-3-carboxylate (1033809-42-5) → 2-chloromethyl-pyridine-3-carboxylic acid methyl ester (177785-14-7)

Guidance literature:

With trichlorophosphate; at 20 ℃; for 3h; Inert atmosphere; Reflux;

Reference yield:

methyl 2-methyl-1-oxo-1lambda5-pyridine-3-carboxylate (1033809-42-5) → methyl 6-chloro-2-methylpyridine-3-carboxylate (851759-19-8) + 2-chloromethyl-pyridine-3-carboxylic acid methyl ester (177785-14-7)

Guidance literature:

3-(methoxycarbonyl)-2-methylpyridine 1-oxide; With trichlorophosphate; for 3h; Reflux;

With water; at 20 ℃;

With sodium carbonate; In water;

upstream raw materials:

methyl 2-methylnicotinate

trichloroisocyanuric acid

methyl 2-methyl-1-oxo-1lambda5-pyridine-3-carboxylate

Downstream raw materials:

2-(2-formyl-pyrrol-1-yl-methyl)-pyridine-3-carboxylic acid methyl ester

2-chloro-6-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

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