1,9-Dioxa-4-azacyclododecane-3,8,12-trione, 10-heptyl-6-hydroxy-11-methyl-2-(1-methylethyl)-5-(phenylmethyl)-, (2S,5S,6R,10R,11S)-

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Chemical Name:1,9-Dioxa-4-azacyclododecane-3,8,12-trione, 10-heptyl-6-hydroxy-11-methyl-2-(1-methylethyl)-5-(phenylmethyl)-, (2S,5S,6R,10R,11S)-
CAS No.:178113-59-2
Molecular Formula:C27H41NO6
Molecular Weight:475.626
Hs Code.:

Synonyms:

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Chemical Property of 1,9-Dioxa-4-azacyclododecane-3,8,12-trione, 10-heptyl-6-hydroxy-11-methyl-2-(1-methylethyl)-5-(phenylmethyl)-, (2S,5S,6R,10R,11S)-

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Technology Process of 1,9-Dioxa-4-azacyclododecane-3,8,12-trione, 10-heptyl-6-hydroxy-11-methyl-2-(1-methylethyl)-5-(phenylmethyl)-, (2S,5S,6R,10R,11S)-

There total 26 articles about 1,9-Dioxa-4-azacyclododecane-3,8,12-trione, 10-heptyl-6-hydroxy-11-methyl-2-(1-methylethyl)-5-(phenylmethyl)-, (2S,5S,6R,10R,11S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 178113-60-5
(2S,5S,6R,10R,11S)-5-Benzyl-6-(tert-butyl-dimethyl-silanyloxy)-10-heptyl-2-isopropyl-11-methyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

: 178113-59-2
N-desmethylhapalosin

Guidance literature:: With pyridine; hydrogen fluoride; In tetrahydrofuran; at 25 ℃; for 18h;
DOI:10.1021/jo9608329

Reference yield:

: 124-13-0
Octanal

: 178113-59-2
N-desmethylhapalosin

Guidance literature:: Multi-step reaction with 11 steps

2: 100 percent / pyridine, DMAP / CH₂Cl₂ / 1.17 h / 0 - 25 °C

4: KBH₄ / ethanol / 6.5 h / 0 °C

5: 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

6: 1) O₃, 2) PPh₃ / 1) CH₂Cl₂, MeOH, -78 deg C, 3 min, 2) CH₂Cl₂, MeOH, 25 deg C, 15 h

7: 100 percent / NaClO₂, 2-methyl-2-butene, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 16 h / 25 °C

8: 85 percent / EDC, DMAP / CH₂Cl₂ / 17 h / 25 °C

9: H₂ / Pd(OH)2/C / methanol / 30 h / 25 °C / 760 Torr

10: i-Pr₂NEt, BOP-Cl / toluene / 15 h / 85 °C

11: 71 percent / HF, pyridine / tetrahydrofuran / 18 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium chlorite; sodium dihydrogenphosphate; potassium borohydride; 2-methyl-but-2-ene; hydrogen fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1021/jo9608329

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 178113-59-2
N-desmethylhapalosin

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / DBU / acetonitrile / 17 h / 25 °C

2: 85 percent / EDC, DMAP / CH₂Cl₂ / 17 h / 25 °C

3: H₂ / Pd(OH)2/C / methanol / 30 h / 25 °C / 760 Torr

4: i-Pr₂NEt, BOP-Cl / toluene / 15 h / 85 °C

5: 71 percent / HF, pyridine / tetrahydrofuran / 18 h / 25 °C

With pyridine; dmap; hydrogen fluoride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo9608329